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CU Child Neurology Neuroimmunology > Paraneoplastic/Antibody-Mediated Syndromes > Flashcards

Paraneoplastic/Antibody-Mediated Syndromes Flashcards

1
Q

Anti-NMDA receptor

A

ovarian teratoma; causes limbic encephalitis; psychosis, dyskinesias

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2
Q

Anti-AMPA receptor

A

breast cancer, lung cancer, thymoma; causes limbic encephalitis, nystagmus

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3
Q

Anti-GABA-B receptor

A

SCLC; causes limbic encephalitis, orolingual dyskinesias

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4
Q

Anti-LGI1

A

SCLC, thymoma; causes limbic encephalitis

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5
Q

Anti-CV2; CRMP5 IgG

A

SCLS, thymoma; causes limbic encephalitis; aphasia, chorea, ataxia, myelopathy, radiculopathy, neuropathy, LEMS

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6
Q

Anti-Hu (ANNA1)

A

SCLC; causes limbic encephalitis; autonomic, peripheral, sensory neuropathy.

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7
Q

Anti-Ma2

A

testicular cancer; causes limbic encephalitis, hypothalamic/pituitary disorder

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8
Q

Anti-GAD65

A

SCLC, thymoma, renal cell, breast, colon; causes limbic encephalitis, stiff man syndrome, ataxia, ophthalmoplegia, parkinsonism, myelopathy

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9
Q

Anti-Yo (PCA1)

A

ovarian, breast cancer; causes cerebellar ataxia, brainstem encephalitis, myelopathy, radiculopathy, peripheral neuropathy

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10
Q

PCA-2

A

SCLC; limbic encephalitis, LEMS, peripheral and autonomic neuropathy

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11
Q

Anti-Tr (PCA-Tr)

A

Hodgkin lymphoma; cerebellar ataxia

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12
Q

Anti-Ri (ANNA2)

A

SCLC, breast cancer; dementia, limbic encephalitis, myelopathy, peripheral neuropathy

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13
Q

Anti-Hu (ANNA1) in peds

A

Neuroblastoma in children with opsoclonus-myoclonus syndrome

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14
Q

ANNA-3

A

lung, esophageal cancer; limbic encephalitis, myelopathy, peripheral neuropathy

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15
Q

AGNA

A

SCLC; limbic encephalitis, LEMS, neuropathy

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16
Q

Amphiphysin IgG

A

SCLC, breast cancer; limbic encephalitis, aphasia, Stiff person, myelopathy, neuropathy

17
Q

Anti-Ma1/Ma2

A

breast, colon, testicular cancer; limbic encephalitis, hypothalamic/pituitary disorder

18
Q

Anti-VGKC complex (LGI1 or CASPR2)

A

SCLC, thymoma, breast, prostate; limbic encephalitis, hypothalamic disorder, EPS, myoclonus, peripheral and autonomic neuropathy

19
Q

Anti-P/Q, N-type Calcium channel (VGCC)

A

SCLC, breast, gyn cancer; encephalopathy, myelopathy, neuropathy, LEMS

20
Q

Anti-NMO

A

thymoma; relapsing optic neuritis, transverse myelitis, encephalopathy

21
Q

Anti-neuronal ganglionic AChR

A

SCLC, thymoma, other AC; dysautonomia

22
Q

Anti-muscle AChR

A

thymoma, lung cancer; MG

23
Q

Anti-glycine receptor

A

Stiff man syndrome

24
Q

Anti-GluR5

A

Hodgkin lymphoma; limbic encephalitis

25
Q

Painless visual loss with night blindness, light induced glare, photosensitivity, peripheral ring like scotomas; normal fundoscopy

A

retinopathy associated with CRMP-5; Anti-recoverin

26
Q

Memory problems, personality change, focal seizures, altered mood. T2 hyperintensity in hippocampi

A

limbic encephalitis

27
Q

vision disturbance, tremulousness, disturbed sleep, screaming spells. Lightning like irregular movements of the eyes and limbs

A

opsoclonus-myoclonus; Anti-Hu (ANNA1)

28
Q

diplopia, vertigo, nausea, vomiting, ataxic dysarthria, nystagmus, gait, limb incoordination

A

Anti-Yo (PCA1); Anti-P/Q type calcium channel; Anti-Tr (PCA-Tr)

29
Q

Chorea

A

CRMP-5 IgG

30
Q

Parkinsonism, cranial neuropathies, disorders of eye movement and balance

A

brainstem encephalitis, Anti-Ma1/Ma2

31
Q

Jaw dystonia, paroxsymal laryngeal spasm

A

Anti-Ri (ANNA2)

32
Q

Myelopathy with T2 signal abnormalities on MRI and oligoclonal bands

A

CRMP-5 IgG, amphiphysin Ab, NMO, MS

33
Q

stiffness and spams of lumbar and proximal lower extremities, exaggerated startle response, loss of protective reflexes while falling

A

Stiff man syndrome, Ampiphysin IgG, Anti-GAD65, Anti-Glycine receptor; often associated with T1DM and autoimmune thyroid disease

34
Q

mydriasis, dry mouth, early satiety, nausea, small bowel pseudo-obstruction, constipation, orthostatic HoTN, heat intolerance, bladder symptoms

A

dysautonomia, ANNA-1; Anti-neuronal ganglionic AChR

35
Q

subacute progressive fatigue, weakness, worsens with exertion and improves with rest

A

LEMS; Anti-P/Q, N-type Calcium channel; Anti-CV2; CRMP5 IgG; PCA-2; AGNA

36
Q

Anti-MAG

A

Waldenstrom macroglobulinemia; peripheral neuropathy

CU Child Neurology Neuroimmunology (6 decks)

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