Continuum Demyelinating disease questions

Question 1

What percent of patients who meet radiologically isolated syndrome (RIS) go on to develop MS in the next 5 years?

Answer 1

33%

Question 2

what percentage of pts with MS have symptom onset before the age of 18?

Answer 2

2 to 10%

Question 3

What disease modifying therapy requires accelerated elimination procedure in the event of pregnancy?

Answer 3

Teriflunomide; Without accelerated ellimination procedure, Teriflunomide stays in the body up to two years; category X drug
elimination by cholestyramine 3x per day for 11 days or activated charcoal

Question 4

What MRI findings are relatively specific to CADASIL? (2)

Answer 4

1. prominent involvement of the external capsule and anterior temporal regions
2. subcortical micro-hemorrhages

Question 5

What are clinical or radiographical findings that could be helpful in telling early on if a patient has aggressive subtype of MS?

Answer 5

Clinical fx: male gender, multifocal attacks, impairments in activities of daily living
Radiographical fx: currently no reliable imaging to tell aggressive vs less aggressive form of disease