MS Neuro-pharmacology

Question 1

Three broad categories of MS drug delivery

Answer 1

injectable, oral, infusions

Question 2

3 injectables

Answer 2

interferon 1b and 1a (neutralizing abs form), glatiramer acetate (safe in pregnancy)

Question 3

Name 3 oral drugs for MS

Answer 3

dimethyl fumurate (tecFIDera), Fingolimod (Gilenya), Teriflunomide (aubagio, category x in pregnancy)

Question 4

4 infusions

Answer 4

natalizumab (tysabri), alemtuzumab (lemtrada), ocrelizumbad (ocrevus),
dalfampridine (ampyra)

Question 5

Name the MS drug: increase risk of seizure, improves ambulation

Answer 5

dalfampridine (ampyra)

Question 6

Name the MS drug: CD52 binder, check thyroid, kidney and platelets

Answer 6

alemtuzumab (lemtrada)

Question 7

Name the MS drug: anti CD 20 , fancy rituximab

Answer 7

ocrevus (ocrelizumab)

Question 8

Name the MS drug: highest risk of JC/PML, blocks t-cells from crossing BBB

Answer 8

natalizumab (tysabri)

Question 9

Name the MS drug: contraindicated in pregnancy (2 years prior to conception) and cirrhosis, alopecia

Answer 9

Teriflunimide (aubagio)

Question 10

Name the MS drug: inhibitos DHODH (dihydroorotate dehydrogenase)

Answer 10

Teriflunimide (aubagio)

Question 11

Name the MS drug: first dose observation for bradycardia, inhibiits S1P receptors (sphingosine-1-phosphate) which sequesters T-cells in lymphocytes

Answer 11

fingolimod (gilenya)