Paramedic Medications Flashcards
What is the trade name of Atropine
Atreza
What is the mechanism of action of Atropine
Blocks muscarinic receptors blocking acetylcholine and inhibiting the effects of the parasympathetic nervous system
What drug class is Atropine
Parasympatholytic, Muscarinic Anticholinergic
Indications for Atropine
Bradycardia
Organophosphate poisoning
RSI premedication
Contraindications for Atropine
Hypersensitivity, 2nd or 3rd degree heart block
Common side effects of Atropine
Dry Mouth, Dilated Pupils, Confusion, Blurred Vision, Tachycardia
Key drug/drug interactions of Atropine
Anticholinergics: increased effects
What is the adult dose of Atropine
Symptomatic Bradycardia: 1 mg every 3-5 min up to 3 mg max
Organophosphate Poisoning: 2-3 mg IVP every 2-3 min
Pre RSI: 0.01 mg/kg second to repeated dose of succinylcholine
What is the pediatric dose of Atropine
Symptomatic Bradycardia: 0.01-0.03 mg/kg every 3-5 min max dose 1 mg (Child)/2mg (Adolescent)
Organophosphate Poisoning:
Pre RSI: 0.02 mg/kg
Is Atropine a standing order or only administered under medical direction?
Standing Order Unless:
Adult Organophosphate Poisoning with HR > 120 bpm
What is the trade name of Calcium Chloride
Artiss, Citraste
What is the mechanism of action of Calcium Chloride
Raises Calcium Levels
What drug class is Calcium Chloride
Mineral/Electrolyte, Antidote, Inorganic compound
Indications for Calcium Chloride
Calcium Channel blocker overdose
Sulfate Overdose
Hyperkalemia/Hypocalcemia inducing EKG changes
Contraindications for Calcium Chloride
Ventricular Fibrillation
Asystole
Hypersensitivity
Common side effects of Calcium Chloride
Abnormal Heartbeat Feeling, Polyuria, Dizziness, Mood Changes
Key drug/drug interactions of Calcium Chloride
Diltiazem: Increases effects
Digoxin: May cause arrhythmias
Ceftriaxone: Creates insoluble particles
What is the adult dose of Calcium Chloride
1 g slow IVP
What is the pediatric dose of Calcium Chloride
20 mg/kg IVP
Is Calcium Chloride a standing order or only administered under medical direction?
Standing Order Unless:
Adult dysrhythmia
Pediatric usage
Sulfate Toxicity
What is the trade name of Calcium Gluconate
Kalcinate
What is the mechanism of action of Calcium Gluconate
Raises Calcium Levels
What drug class is Calcium Gluconate
Mineral/Electrolyte, Antidote, Inorganic compound
Indications for Calcium Gluconate
Calcium Channel blocker overdose
Sulfate Overdose
Hyperkalemia/Hypocalcemia inducing EKG changes
Contraindications for Calcium Gluconate
Hypercalcemia
Hypersensitivity
Common side effects of Calcium Gluconate
Chalky Taste, Constipation, Odd Heart Beat Feeling
Key drug/drug interactions of Calcium Gluconate
Ceftriaxone: Creates insoluble particles
Digoxin: May cause arrhythmias
What is the adult dose of Calcium Gluconate
3 g IVP
What is the pediatric dose of Calcium Gluconate
60 mg/kg IVP
Is Calcium Gluconate a standing order or only administered under medical direction?
Standing Order Unless:
Adult dysrhythmia
Pediatric usage
Sulfate Toxicity
What is the trade name of Metoprolol
Lopressor, Toprol, Kapspargo Sprinkle
What is the mechanism of action of Metoprolol
Blocks Beta 1 adrenergic receptors
What drug class is Metoprolol
Beta Blocker
Indications for Metoprolol
Hypertension
Angina
Prevention of MI
Stable symptomatic heart failure
Contraindications for Metoprolol
Uncompensated Heart Failure
Pulmonary Edema
Cardiogenic Shock
Bradycardia, Heart Block, SSS without pacemaker
Common side effects of Metoprolol
Bradycardia, Heart Failure, Hypotension, Vasoconstriction, Fatigue, Weakness, Dizziness, Drowsiness, Pulmonary Edema
Key drug/drug interactions of Metoprolol
Anesthesia: Myocardial depression
Diltiazem, Digoxin: Bradycardia
Epinephrine (All forms): Excessive Alpha Adrenergic stimulation
What is the adult dose of Metoprolol
IV: 5 mg every 2-3 min
PO: 25-100 mg/day
What is the pediatric dose of Metoprolol
PO: 1 mg/kg daily
Is Metoprolol a standing order or only administered under medical direction?
Medical Direction
What is the trade name of Ketamine
Ketalar
What is the mechanism of action of Ketamine
Antagonizes NMDA receptors to produce analgesic and anesthetic effects
What drug class is Ketamine
Dissociative Anesthetic
Indications for Ketamine
RSI
Anesthetic
Sedation
Contraindications for Ketamine
Pregnancy & Lactation
Significant Hypertension
Head Trauma & Elevated ICP
Risk of aortic dissection, aneurysm, or myocardial infarction
Allergy to ketamine
Common side effects of Ketamine
Bradycardia, Bradypnea, myoclonus, Nausea, Vomiting, Confusion, Dizziness, Drowsiness, Rise in blood pressure, Apnea, Delirium, Dissociation
Key drug/drug interactions of Ketamine
CNS Depressants, benzodiazepines, and opioid analgesics: May increase sedation leading to respiratory depression and coma
Sympathomimetics: Increases sympathomimetic effects of ketamine
Theophylline: Lowers seizure threshold
What is the adult dose of Ketamine
Pain:
IM: 50 mg Repeated once in 10 min
IV/IO: 25 mg repeated once in 10 minutes
Initial RSI dose:
2 mg/kg
Sedation:
0.1-0.5 mg/min IV
What is the pediatric dose of Ketamine
RSI:
IV: 2 mg/kg
IM: 4 mg/kg
Pain:
IM: 25 mg Repeated once after 10 min
Sedation:
IV: 0.5-1 mg/kg
IM: 2 mg/kg
Is Ketamine a standing order or only administered under medical direction?
Standing order
What is the trade name of Ketorolac
Toradol
What is the mechanism of action of Ketorolac
Inhibits cyclooxygenase to prevent the genesis of prostaglandins, prostacyclin, and thromboxane. This this prevents inflammation and fever
What drug class is Ketorolac
Nonsteroidal anti-inflammatory (NSAID)
Indications for Ketorolac
Renal Colic
Pain
Fever
Inflammation
Contraindications for Ketorolac
Hypersensitivity, Thrombosis, Gastrointestinal Risk/Bleeding/Ulcers, Renal Failure/Disease, Blood Thinners, Anticoagulant Usage, Internal Bleeding Suspected
Common side effects of Ketorolac
Nausea, Vomiting, GI Bleeding, Stomach Pain, Hypertension, Indigestion
Key drug/drug interactions of Ketorolac
NSAIDs, SSRIs: Increased risk of side effects such as gastrointestinal bleeding
Probenecid, Lithium: Increases plasma levels and duration
Pentoxifylline: Increased risk of bleeding
What is the adult dose of Ketorolac
IV: 15 mg
IM: 30 mg
What is the pediatric dose of Ketorolac
IV: 0.5 mg/kg (Max dose 15 mg)
IM: 1 mg/kg (Max dose 30)
Is Ketorolac a standing order or only administered under medical direction?
Standing order unless:
Pediatric administration
What is the trade name of Fentanyl
Sublimaze
What is the mechanism of action of Fentanyl
Binds to opioid receptors in the nervous system, inhibiting nociceptors and creating an analgesic effect
What drug class is Fentanyl
Narcotic Analgesic, Opioid
Indications for Fentanyl
Pain
Pre/post RSI when Increased ICP
Contraindications for Fentanyl
Allergy
Common side effects of Fentanyl
Respiratory Depression, Euphoria, Confusion, Drowsiness, Nausea, Hypotension, Coma, Constipation, Chest Rigidity
Key drug/drug interactions of Fentanyl
Naloxone: Antagonist
Benzodiazepines
What is the adult dose of Fentanyl
Pain:
IM: 1 mcg/kg (Max dose 100 mcg)
IV: 25-50 mcg (Max dose 300 mcg)
IN: 2 mcg/kg (Max dose 100 mcg)
RSI:
IV/IO: 3 mcg/kg
What is the pediatric dose of Fentanyl
Pain:
IV/IO/IM: 1 mcg/kg (Max dose 3 mcg)
IN: 2 mcg/kg (Max 100 mcg)
RSI:
IV/IO: 3 mcg/kg
Is Fentanyl a standing order or only administered under medical direction?
Standing order unless:
Administering > 3 doses to a pediatric patient/ exceeding max dose
What is the trade name of Hydromorphone Hydrochloride
Dilaudid
What is the mechanism of action of Hydromorphone Hydrochloride
Binds to opioid receptors in the nervous system, inhibiting nociceptors and creating an analgesic effect
What drug class is Hydromorphone Hydrochloride
Narcotic Analgesic, Opioid
Indications for Hydromorphone Hydrochloride
Extreme pain
Contraindications for Hydromorphone Hydrochloride
Hypersensitivity, Respiratory Depression, Asthma, Gastrointestinal Obstructions, Hypotension, Labor
Common side effects of Hydromorphone Hydrochloride
Nausea, Vomiting, Respiratory Depression, Dizziness, Increased ICP, Coma, Seizure
Key drug/drug interactions of Hydromorphone Hydrochloride
Naloxone: Antagonist
Safinamide, Tricyclic antidepressants, serotonin reuptake inhibitors: Serotonin Syndrome
CNS depressants: Respiratory depression
What is the adult dose of Hydromorphone Hydrochloride
IV: 1-2 mg
What is the pediatric dose of Hydromorphone Hydrochloride
0.015 mg/kg
Is Hydromorphone Hydrochloride a standing order or only administered under medical direction?
Standing order unless used on a pediatric patient
What is the trade name of Morphine
Kadian, Depodur, Infumorph, Duramorph
What is the mechanism of action of Morphine
Binds to opioid receptors in the nervous system, inhibiting nociceptors and creating an analgesic effect
What drug class is Morphine
Narcotic Analgesic, Opioid
Indications for Morphine
Acute Pain
Contraindications for Morphine
Allergy, Hypotension
Common side effects of Morphine
Vasodilation, Respiratory Depression, Itching, Pupil Constriction, Sweating, Dizziness, Numbness, Bradycardia, Tachycardia, Hypotension, Syncope, Constipation
Key drug/drug interactions of Morphine
Naloxone: Antagonist
MAOIs: Increases effects
Alcohol: Increases Plasma levels
What is the adult dose of Morphine
0.1 mg/kg IV/IO/IM (Repeatable up to 10 mg)
What is the pediatric dose of Morphine
0.1-0.2 mg/kg
Is Morphine a standing order or only administered under medical direction?
Standing order unless:
Exceeding standing order max dose in an adult patient
What is the trade name of Etomidate
Amidate
What is the mechanism of action of Etomidate
Increases effects of Gaba-aminobutyric acid and lowers work of excitatory neurotransmitters to cause sedation, anesthesia, and hypnosis
What drug class is Etomidate
General Anesthetic/Sedative hypnotic
Indications for Etomidate
RSI
Contraindications for Etomidate
Allergy
Common side effects of Etomidate
Nausea, Vomiting, myoclonus
Key drug/drug interactions of Etomidate
Glutides: May induce vomiting
Esketamine: Increases effects
Isocarboxazid, selegiline, tranylcypromine, Sodium Oxybate: Increases blood pressure
What is the adult dose of Etomidate
0.1-0.3 mg/kg IVP over 15-30 seconds
What is the pediatric dose of Etomidate
0.1-0.3 mg/kg IVP over 15-30 seconds
Is Etomidate a standing order or only administered under medical direction?
Standing Order
What is the trade name of Midazolam
Versed
What is the mechanism of action of Midazolam
Increases effects of Gaba-aminobutyric acid, causing sedation, muscle relaxation, amnesia, and anesthesia
What drug class is Midazolam
Benzodiazepine
Indications for Midazolam
Seizure
Sedation
Post RSI sedation
Acute Alcohol Withdrawal
Contraindications for Midazolam
Hypersensitivity, alcohol intoxication, Acute narrow angle glaucoma, epidural use, shock
Common side effects of Midazolam
Bradypnea, Apnea, Nausea, Vomiting, hypotension, bradycardia, myoclonus, arrhythmias, bronchospasms
Key drug/drug interactions of Midazolam
Depressants: Increases risk of respiratory depression
Lorazepam, diphenhydramine, cannabidiol, levetiracetam, Valium: Increases and prolongs effects
Alcohol
What is the adult dose of Midazolam
Seizure: 2mg/kg IV/IO or 4mg IM. Repeat 2 mg after 2 min if needed
RSI: 0.1 mg/kg, 6mg if >60lbs
Sedation: 2mg
What is the pediatric dose of Midazolam
0.1 mg/kg
Is Midazolam a standing order or only administered under medical direction?
Standing order unless exceeding recommended doses
What is the trade name of Proparacaine HCL
Alcaine
What is the mechanism of action of Proparacaine HCL
Prevents ophthalmic nerve excitation by hindering sodium channels
What drug class is Proparacaine HCL
Ophthalmic anesthetic
Indications for Proparacaine HCL
Acute eye pain
Contraindications for Proparacaine HCL
Hypersensitivity, Rupture
Common side effects of Proparacaine HCL
Redness, Burning, Stinging
Key drug/drug interactions of Proparacaine HCL
Bupivacaine: Methemoglobinemia
What is the adult dose of Proparacaine HCL
1-2 drops
What is the pediatric dose of Proparacaine HCL
1-2 drops
Is Proparacaine HCL a standing order or only administered under medical direction?
Standing order
What is the trade name of Lidocaine
Xylocaine
What is the mechanism of action of Lidocaine
Prevents/slows cell depolarization by keeping sodium channels open
What drug class is Lidocaine
Local Anesthetic, Antiarrhythmic
Indications for Lidocaine
Ventricular Tachycardia
Local anesthetic (IO, etc)
Ventricular fibrillation not responding to alternative interventions
RSI premedication in patients with Increased ICP
Contraindications for Lidocaine
IV Calcium Channel Blockers
Allergy
Common side effects of Lidocaine
Drowsiness, Slurred speech, Confusion, Seizures, Hypotension
Key drug/drug interactions of Lidocaine
Propranolol: Increase concentration
Fluvoxamine
Xanax, Metoprolol, cyclobenzaprine, duloxetine, lorazepam: Increase effects
Acetaminophen: Methemoglobinemia
What is the adult dose of Lidocaine
1-1.5 mg/kg IVP
What is the pediatric dose of Lidocaine
1-1.5 mg/kg IVP
Is Lidocaine a standing order or only administered under medical direction?
Standing order
What is the trade name of Diazepam
Valium, Libervant, Diastat,
What is the mechanism of action of Diazepam
Binds to receptors in the brain and spinal cord to increase the effects of GABA (Gaba-aminobutyric acid) to cause anti-convulsant, amnesiac, sedative, and muscle relaxant effects.
What drug class is Diazepam
Benzodiazepine, Anti-Convulsant
Indications for Diazepam
Seizure
Contraindications for Diazepam
Pediatrics <6 months, narrow angle glaucoma, hypersensitivity, Myasthenia Gravis Disease, Respiratory insufficiency, Sleep apnea
Common side effects of Diazepam
Drowsiness, fatigue, weakness, headache, incontinence, confusion, sedation, nausea
Key drug/drug interactions of Diazepam
Grapefruit, fluoxetine, chloramphenicol, carbamazepine, topiramate, phenytoin: Increases concentration
Depressants: Respiratory depression, sedation, and hypotension
What is the adult dose of Diazepam
2-10 mg IVP, IM, IO every 3-5 minutes prn up to 20 mg
What is the pediatric dose of Diazepam
0.1-0.3 mg/kg IVP/IM/IO up to 5 mg repeated once prn
Is Diazepam a standing order or only administered under medical direction?
Standing order
What is the trade name of Droperidol
Inapsine
What is the mechanism of action of Droperidol
Subcortical CNS Depression
What drug class is Droperidol
Butyrophenones, Sedative/Hypnotic
Indications for Droperidol
Antinausea
Sedative
Contraindications for Droperidol
Hypersensitivity
Angle-closure Glaucoma
Bone Marrow Depression
CNS Depression
QT interval prolongation
Lactation
Common side effects of Droperidol
Hypotension, Tachycardia, Constipation, Blurred Vision, Bronchospasm, Laryngospasm, Seizures, Arrhythmias
Key drug/drug interactions of Droperidol
Nitrates, Antihypertensives: Hypotension
CNS depressants: Increased CNS depression
What is the adult dose of Droperidol
2.5 mg
What is the pediatric dose of Droperidol
0.01-0.075 max dose 1.25
Is Droperidol a standing order or only administered under medical direction?
MD order
What is the trade name of Ziprasidone
Geodon, Zeldox
What is the mechanism of action of Ziprasidone
Antagonized Type 2 dopamine, Serotonin, and adrenergic receptors
What drug class is Ziprasidone
Antipsychotic
Indications for Ziprasidone
Schizophrenia
Agitated patients
Contraindications for Ziprasidone
Hypersensitivity
Prolonged QT interval
Hyperkalemia
Hypomagnesemia
Common side effects of Ziprasidone
QT Interval Prolongation, SJS, Urticaria, Rhinorrhea, Hyperglycemia, Diarrhea, Agranulocytosis, Dizziness, Drowsiness, Neuroleptic Malignant Syndrome
Key drug/drug interactions of Ziprasidone
Antiarrhythmics
Alcohol, Antidepressants, Antihistamines, Opioid analgesics, Sedative/Hypnotics: Increased risk of CNS depression
Carbamazepine: Decreases effects
Ketoconazole: Increases effects
What is the adult dose of Ziprasidone
10-20 mg prn up to 40 mg/kg per day
What is the pediatric dose of Ziprasidone
0.2 mg/kg max dose 20mg (Geoden is not tested in pediatrics. Contact Medical Control, there is no finalized dose
Is Ziprasidone a standing order or only administered under medical direction?
Standing Order Unless:
Pediatric
What is the trade name of Lorazepam
Ativan
What is the mechanism of action of Lorazepam
CNS depressant that affects GABA
What drug class is Lorazepam
Benzodiazepine, Sedative/Hypnotic, Anti Anxiety
Indications for Lorazepam
Anxiety
Status Epilepticus
Sedation
Contraindications for Lorazepam
Hypersensitivity
Comatose
Severe pain
Sleep apnea
Severe hypotension
Comatose
Common side effects of Lorazepam
Apnea, Cardiac Arrest, Bradycardia, Hypotension, Blurred vision, Respiratory depression, Dizziness, Drowsiness, Ataxia, Confusion
Key drug/drug interactions of Lorazepam
Other Benzos, Alcohol, Opioids: Respiratory depression
Valproate, Probenecid: Increases levels
Nicotine: Lowers effectiveness
What is the adult dose of Lorazepam
Status Epilepticus:
IV/IM: 4 mg
Anxiety:
Contact Medical control
Is Lorazepam a standing order or only administered under medical direction?
Standing Order Unless
Pediatric
What is the trade name of Hydroxocobalamin
Cyanokit
What is the mechanism of action of Hydroxocobalamin
Is necessary for metabolic processes, cell reproduction, and hematopoiesis
What drug class is Hydroxocobalamin
Antianemic
Indications for Hydroxocobalamin
Cyanide Poisoning
Contraindications for Hydroxocobalamin
Hypersensitivity
Lactation
Common side effects of Hydroxocobalamin
Hypertension, Chest Pain, Edema, Tachycardia, dizziness, Headache, Red urine, Acute renal failure, dyspnea, Nausea, Vomiting
Key drug/drug interactions of Hydroxocobalamin
Colchicine
Alcohol
Chloramphenicol
Antineoplastics
What is the adult dose of Hydroxocobalamin
5 g over 15 min
What is the pediatric dose of Hydroxocobalamin
70 mg/kg max dose 5 g
Is Hydroxocobalamin a standing order or only administered under medical direction?
Medical Direction
What is the mechanism of action of Sodium Bicarbonate
Increases bicarbonate and blood PH to lower systemic acid levels.
What drug class is Sodium Bicarbonate
Minerals/Electrolytes, Antacids, Alkalinizing
Indications for Sodium Bicarbonate
Renal Failure
Tricyclic Overdose
Hyperkalemia induced Dysrhythmias or cardiac arrest
Crush Syndrome
Contraindications for Sodium Bicarbonate
Non in the prehospital setting
Common side effects of Sodium Bicarbonate
Alkalosis, Headache, Muscle Pain, Nausea, Bradypnea, Polyuria, Vomiting, Nervousness
Key drug/drug interactions of Sodium Bicarbonate
Incompatible with other drugs. Use a separate line or flush the line well before and after use
What is the adult dose of Sodium Bicarbonate
Cardiac Arrest with TCA overdose or hyperkalemia: 1 mEq/kg IVP or 50 mEq over 5 min
Dysrhythmia from tricyclic use or hyperkalemia:1 mEq/kg IVP or 50 mEq over 5 min
Crush Syndrome: 50 mEq/hr max 150
What is the pediatric dose of Sodium Bicarbonate
Cardiac Arrest with TCA overdose or hyperkalemia: 1 mEq/kg IVP
Dysrhythmia from tricyclic use or hyperkalemia: 1 mEq/kg IVP
Is Sodium Bicarbonate a standing order or only administered under medical direction?
Standing Order unless used for pediatric dysrhythmia
What is the trade name of Naloxone HCL
Narcan
What is the mechanism of action of Naloxone HCL
Prevents opiate binding to receptors sites by binding in its place.
What drug class is Naloxone HCL
Opioid Antagonist
Indications for Naloxone HCL
CNS depression due to opioid overdose
Contraindications for Naloxone HCL
Non in the prehospital setting
Common side effects of Naloxone HCL
Ventricular Arrhythmia, hyper/hypotension, combativeness
Key drug/drug interactions of Naloxone HCL
Opiates: Antagonizes
What is the adult dose of Naloxone HCL
IN/IV/IM:0.5 mg repeated up to 2 mg
What is the pediatric dose of Naloxone HCL
IN/IV/IM:0.5 mg repeated up to 2 mg
Is Naloxone HCL a standing order or only administered under medical direction?
Standing order
What is the trade name of Activated Charcoal
Insta-Char, Acta Char, Actidose
What is the mechanism of action of Activated Charcoal
Binds to and neutralizes drugs and toxins in the digestive tract, causing them to be passed through the system with little to no absorption
What drug class is Activated Charcoal
Absorbent
Indications for Activated Charcoal
Oral Poisoning
Contraindications for Activated Charcoal
poisoning by Cyanide, corrosives, ethanol, iron, mineral acids, solvents, methanol, Altered LOC
Common side effects of Activated Charcoal
Discolored stool, Nausea, vomiting, GI upset
Key drug/drug interactions of Activated Charcoal
Activated charcoal will bind to most drugs in the system and negate their effects
What is the adult dose of Activated Charcoal
1g/kg (Dose may be altered at jurisdiction of physician)
What is the pediatric dose of Activated Charcoal
1g/kg (Dose may be altered at jurisdiction of physician)
Is Activated Charcoal a standing order or only administered under medical direction?
Medical direction
What is the trade name of Pralidoxime Chloride
Protopam
What is the mechanism of action of Pralidoxime Chloride
Reactivates cholinesterase to reverse poisonings
What drug class is Pralidoxime Chloride
Antidote, Cholinesterase reactivator
Indications for Pralidoxime Chloride
Organophosphate Poisoning
Contraindications for Pralidoxime Chloride
Hypersensitivity
Common side effects of Pralidoxime Chloride
Tachycardia, Blurred vision, Weakness, Rigidity, Dizziness,, Headache, Laryngospasm, hyperventilation
Key drug/drug interactions of Pralidoxime Chloride
Opioids, Sedative/Hypnotics
What is the adult dose of Pralidoxime Chloride
1200-1800 mg
What is the pediatric dose of Pralidoxime Chloride
20-50 mg
Is Pralidoxime Chloride a standing order or only administered under medical direction?
Standing order unless pediatric administration
What is the trade name of Prochlorperazine
Compazine
What is the mechanism of action of Prochlorperazine
Inhibits chemoreceptors in CNS and has anticholinergic effects. Alters dopamine levels in CNS.
What drug class is Prochlorperazine
Phenothiazines, Antipsychotic
Indications for Prochlorperazine
Nausea
Vomiting
Contraindications for Prochlorperazine
Hypersensitivity
Liver/cardiovascular disease
Pediatrics younger than 2
Angle-closure glaucoma
Bone marrow depression
Common side effects of Prochlorperazine
EKG Changes, Hypotension, Tachycardia, Blurred vision, sedation, Neuroleptic Malignant Syndrome
Key drug/drug interactions of Prochlorperazine
Antacids: Lowers absorption
Lithium: Extrapyramidal reaction risk
Anticholinergic drugs: Increases effects
CNS depressants: Increased CNS depression
Nitrates, Antihypertensives: Hypotension
What is the adult dose of Prochlorperazine
IV: 2.5-10 mg max 40 mg
IM: 5-10 mg every 3-4 hr PRN
What is the pediatric dose of Prochlorperazine
For <12
IM: 132 mcg
Is Prochlorperazine a standing order or only administered under medical direction?
Standing order
What is the trade name of Ondansetron
Zofran
What is the mechanism of action of Ondansetron
Blocks Serotonin receptor sites in vagal nerves and the CNS chemoreceptors to prevent nausea and vomiting.
What drug class is Ondansetron
Antiemetic
Indications for Ondansetron
Nausea and Vomiting
Contraindications for Ondansetron
Hypersensitivity
Apomorphine use
Long QT syndrome
Phenylketonuria
Common side effects of Ondansetron
Torsades de Pointes, Serotonin Syndrome, Steven Johnson Syndrome, Toxic Epidermal Necrolysis, Headache, Dizziness, Drowsiness, Diarrhea, Abdominal Pain, Ischemia
Key drug/drug interactions of Ondansetron
Apomorphine: Hypotension
Serotonin affecting drugs: Serotonin syndrome
What is the adult dose of Ondansetron
PO/IV/IM: 4mg repeated once prn
What is the pediatric dose of Ondansetron
PO/IV/IM: 0.1 mg/kg max dose of 4mg
Is Ondansetron a standing order or only administered under medical direction?
Standing order
What is the trade name of Promethazine
Phenergan
What is the mechanism of action of Promethazine
Blocks histamine, inhibits chemoreception in the medulla, causes CNS depression, and is anticholinergic
What drug class is Promethazine
Antiemetic, Antihistamine, Sedative/Hypnotic
Indications for Promethazine
Nausea/Vomiting
Sedation
Contraindications for Promethazine
Pediatrics <2
Hypersensitivity
Angle Closure Glaucoma
Bladder obstruction
Prostatic Hypertrophy
Common side effects of Promethazine
Bradycardia, hypertension, hypotension, tachycardia, photosensitivity, hepatitis, neuroleptic malignant syndrome
Key drug/drug interactions of Promethazine
CNS depressants: Increases effects
Antipsychotics: Neuroleptic malignant syndrome
MAO inhibitors and drugs with anticholinergic effects: increases anticholinergic effects
What is the adult dose of Promethazine
Sedation:
IM/IV: 25-50 mg
Nausea/Vomiting:
IM/IV: 25 mg
What is the pediatric dose of Promethazine
Sedation:
IM/IV: 0.5-1 mg/kg Max dose 25mg
Nausea/Vomiting:
IM/IV: 0.25-1 mg/kg Max dose 25mg
Is Promethazine a standing order or only administered under medical direction?
Standing order unless an adult re-dose or pediatric <2
What is the trade name of Glucagon
GlucaGen, Evoke, Baqsimi
What is the mechanism of action of Glucagon
Induces glycogenolysis and relaxes smooth muscle
What drug class is Glucagon
Pancreatic
Indications for Glucagon
Severe hypoglycemia
Beta Blocker Overdose
Calcium Channel Blocker Overdose
Contraindications for Glucagon
Hypersensitivity
Insulinopenia
Pheochromocytoma
Common side effects of Glucagon
Hypotension, Cough, Headache, Nausea, Vomiting
Key drug/drug interactions of Glucagon
Beta Blockers: Increase in HR and BP
Epinephrine: Increases duration
Phenytoin: Inhibits
What is the adult dose of Glucagon
Hypoglycemia: 1 mg IV/IM
Overdose: 50-150 mcg
What is the pediatric dose of Glucagon
Hypoglycemia: 0.5 mg
Is Glucagon a standing order or only administered under medical direction?
Standing order unless repeating the dose
What is the trade name of Dextrose
Glutose
What is the mechanism of action of Dextrose
Is a source of carbohydrates for the body
What drug class is Dextrose
Carbohydrate
Indications for Dextrose
Hypoglycemia
Contraindications for Dextrose
Hypersensitivity
Hyperglycemia
Common side effects of Dextrose
Hypokalemia, Hyponatremia, Glycosuria, Hyperglycemia, Hypomagnesemia
Key drug/drug interactions of Dextrose
Insulin, hypoglycemic agents: Increases dosage needs
What is the adult dose of Dextrose
20-50 ml max 25 g per dose IV
What is the pediatric dose of Dextrose
> 6: 0.5-1 g/kg per dose max 25 g IV
5<: 0.25-0.50 g/kg per dose max 25 g IV
Is Dextrose a standing order or only administered under medical direction?
Standing order
What is the trade name of Succinylcholine
Anectine, Quelicin
What is the mechanism of action of Succinylcholine
Binds with nicotinic receptors to induce muscle paralysis
What drug class is Succinylcholine
Depolarizing, Neuromuscular Blocker
Indications for Succinylcholine
Intubation
Contraindications for Succinylcholine
Burns within 72 hours
Trauma within 72 hours
Low cholinesterase activity
Muscle myopathy
Hyperkalemia
Common side effects of Succinylcholine
Hypotension, Respiratory depression, Jaw rigidity, HyperKalemia, hyperthermia, cardiac arrest, muscle tissue breakdown
Key drug/drug interactions of Succinylcholine
Diltiazem, Dexamethasone, methylprednisolone: Prolongs effects
Furosemide: May enhance or dilute effects
Metoclopramide:Increased risk of respiratory depression
What is the adult dose of Succinylcholine
2 mg/kg
What is the pediatric dose of Succinylcholine
First dose:
Infants: 2 mg/kg IV
Adolescents and older children: 1 mg/kg IV
Maintenance:
0.3-0.6 mg/kg IV every 5-10 minutes prn
Is Succinylcholine a standing order or only administered under medical direction?
Standing order unless using on a pediatric patient
What is the trade name of Rocuronium
Zemuron
What is the mechanism of action of Rocuronium
Binds with nicotinic cholinergic receptors in place of acetylcholine to cause muscle paralysis
What drug class is Rocuronium
Neuromuscular Blocking Agent
Indications for Rocuronium
RSI
Intubation
Contraindications for Rocuronium
<3 months of age
Hypersensitivity
Neuromuscular disease
Use of other neuromuscular agents
Common side effects of Rocuronium
Lightheadedness, Headache, confusion, blurry vision, weakness, Q-T prolongation
Key drug/drug interactions of Rocuronium
Phenytoin, Carbamazepine: Lower effects and duration
Local anesthetics, beta-adrenergic blockers, potassium depleting diuretics, succinylcholine: Prolongs effects and intensity
What is the adult dose of Rocuronium
RSI: 1-2 mg/kg IV
Intubation: 0.45-0.6 mg/kgs IV with 0.1-0.2 mg/kg mg/kg IV prn or 0.01-0.12 mg/kg/min
What is the pediatric dose of Rocuronium
RSI: 1-2 mg/kg IV
Intubation: 0.6 mg/kgs IV with 0.075-0.125 mg/kg IV or 0.001 mcg/kg/min
Is Rocuronium a standing order or only administered under medical direction?
Standing order unless Pediatric or
Maintaining paralysis
What is the trade name of Vecuronium
Vecuronium Bromide, Norcuron
What is the mechanism of action of Vecuronium
Binds with nicotinic cholinergic receptors in place of acetylcholine to cause muscle paralysis
What drug class is Vecuronium
Neuromuscular Blocking Agent
Indications for Vecuronium
Anesthesia for intubation
Contraindications for Vecuronium
Hypersensitivity
Common side effects of Vecuronium
Hypocalcemia, Hypokalemia, Hypomagnesemia, respiratory depression, hypotension, edema, tachycardia, bronchospasm
Key drug/drug interactions of Vecuronium
Etomidate, Ativan, diltiazem, Metoprolol, Nimbex, Reglan: Increases effects
Furosemide: Decreases effects
Methylprednisolone: May cause muscle disorders
Midazolam: May alter effects
Anticholinesterases: Reverses effects
What is the adult dose of Vecuronium
Anesthesia: 0.1-0.2 mg/kg
What is the pediatric dose of Vecuronium
Anesthesia: 0.1 mg/kg IVP repeated every hour prn or 0.05-0.07 mg/kg/hr IV
Is Vecuronium a standing order or only administered under medical direction?
Standing order
What is the trade name of Epinephrine
Adrenalin, Anapen, Citanest, Epipen, Lignospan
What is the mechanism of action of Epinephrine
Induces a sympathetic reaction in the body by binding to Alpha and Beta receptors. For example, In Alpha 1 it causes smooth muscle contraction and in Beta 2, bronchodilation.
What drug class is Epinephrine
Sympathomimetic
Indications for Epinephrine
Cardiac Arrest
Anaphylaxis or systemic allergic reactions
Asthma and other restrictive airway diseases
Bradycardia with pulse (Pediatric)
Croup
Contraindications for Epinephrine
None in the prehospital setting
Common side effects of Epinephrine
Anxiety, tremor, palpitations, tachycardia, headache, hypertension
Key drug/drug interactions of Epinephrine
Inhibits effects: Alpha Adrenergic blocker, antihypertensive, vasodilators, diuretics
Increases effects: Beta-Adrenergic blockers, MAO inhibitors, COMT inhibitors
What is the adult dose of Epinephrine
Cardiac Arrest: 0.5-1 mg (10 ml of 10:10000) IVP/IO prn every 4 minutes or 2.0 mg per dose ET
Allergic Reaction/Anaphylaxis: 0.3 mg (0.3 ml of 1:1000)
Allergic Reaction with Cardiovascular Collapse: 0.3 mg slow IVP
Asthma/ Restrive Airway Disease: 0.3 mg IM
Croup: 5mg nebulized
What is the pediatric dose of Epinephrine
Cardiac Arrest: 0.1 mg/kg (10 ml of 10:10000) IVP/IO prn every 4 minutes
Allergic Reaction/Anaphylaxis: 0.01 mg/kg of 1:1000)
Allergic Reaction with Cardiovascular Collapse: 0.01 mg slow IVP
Asthma/ Restrive Airway Disease: 0.01 mg IM
Croup: 5mg nebulized
Is Epinephrine a standing order or only administered under medical direction?
Standing Order unless:
Adult Asthma if patient is > 40 or has a cardiac disease
Pediatric Anaphylaxis via IVP or Max dose when possible
Pediatric Asthma/Restrive Airway Disease
Croup
What is the trade name of Ipratropium
Atrovent
What is the mechanism of action of Ipratropium
Blocks cholinergic receptors inducing smooth muscles relaxation in the bronchioles are raising HR
What drug class is Ipratropium
Anticholinergic
Indications for Ipratropium
Respiratory distress with the presence of bronchospasms, wheezing, and/or COPD
Contraindications for Ipratropium
Allergy or sensitivity
Signs and symptoms of heart failure
Common side effects of Ipratropium
Tachycardia, Nervousness, tremors, dizziness, palpitations, nausea, vomiting, congestion, hypertension, elevated bronchial secretions, and paroxysmal bronchoconstriction (with repeated use)
Key drug/drug interactions of Ipratropium
May have an increased and undesired effect when paired with other anticholinergics
What is the adult dose of Ipratropium
0.5 mg Nebulized in tandem with Atrovent
What is the pediatric dose of Ipratropium
> 5: 0.5 Nebulized in tandem with Atrovent
< 5: 0.25 Nebulized in tandem with Atrovent
Is Ipratropium a standing order or only administered under medical direction?
Standing order
What is the trade name of Albuterol
Ventolin HFA, ProAir HFA, Respiclick, Accuneb
What is the mechanism of action of Albuterol
Binds to Beta-2 receptors inducing relaxation of the bronchioles
What drug class is Albuterol
Adrenergic Bronchodilator
Indications for Albuterol
Respiratory distress with the presence of bronchospasms, wheezing, and/or COPD
Suspected hyperkalemia
Contraindications for Albuterol
Allergy or sensitivity
Signs and symptoms of heart failure
Common side effects of Albuterol
Tachycardia, Nervousness, tremors, dizziness, palpitations, nausea, vomiting, congestion, hypertension, elevated bronchial secretions, and paroxysmal bronchoconstriction (with repeated use)
Key drug/drug interactions of Albuterol
Diuretics: If non potassium sparing, may result in hypokalemia
Beta Blockers: Neutralize the effects
Tricyclic antidepressants and MAOIs: Increase effects
What is the adult dose of Albuterol
1 Dose of the patients MDI PRN
2.5 mg Nebulized with ipratropium PRN
What is the pediatric dose of Albuterol
2.5 mg Nebulized PRN
Is Albuterol a standing order or only administered under medical direction?
Standing order
What is the trade name of Methylprednisolone
Solu-Medrol
What is the mechanism of action of Methylprednisolone
Binds to glucocorticoid receptors, resulting in the blockage of inflammatory genes and cytokines and inhibits T-cell activity
What drug class is Methylprednisolone
Corticosteroid
Indications for Methylprednisolone
Respiratory distress caused by allergic reaction, asthma, allergic reaction, or COPD
Acute Adrenal Insufficiency
Contraindications for Methylprednisolone
Allergy, Fungal infection
Common side effects of Methylprednisolone
Nausea, vomiting, dizziness, headaches, blurred vision, muscle pain
Key drug/drug interactions of Methylprednisolone
Hepatic Enzyme inducers: Increases drug clearance leading to a higher necessary dosage
Hepatic enzyme inhibitors: Decreases drug clearance leading to a lower necessary dosage.
Aspirin: May Cause GI distress or damage
What is the adult dose of Methylprednisolone
125 mg IVP over 1 min minimum or via IM
What is the pediatric dose of Methylprednisolone
2 mg/kg IVP over 1 min minimum or via IM. Max dose 125 mg
Is Methylprednisolone a standing order or only administered under medical direction?
Standing order except for:
Pediatric administration of any kind
or Adrenal insufficiency
What is the trade name of Diphenhydramine
Benadryl
What is the mechanism of action of Diphenhydramine
Antagonizes H1 receptors to prevent histamine function.
What drug class is Diphenhydramine
Antihistamine
Indications for Diphenhydramine
Dystonic reactions
Anaphylaxis
Allergies
Contraindications for Diphenhydramine
Hypersensitivity
Asthma
Lactation
Common side effects of Diphenhydramine
Hypotension, Palpitations, Blurred vision, Headache, Dizziness, Polyuria
Key drug/drug interactions of Diphenhydramine
Antihistamines, Alcohol, Opiates, sedative hypnotics: CNS depression
MAOs, Tricyclic antidepressants: Increased anticholinergic effect
What is the adult dose of Diphenhydramine
50 mg/kg max dose 400 mg
What is the pediatric dose of Diphenhydramine
1 mg/kg
Is Diphenhydramine a standing order or only administered under medical direction?
Standing Order Unless
Pediatric Combativeness
Pediatric Dystonic reaction
What is the trade name of Magnesium Sulfate
Epsom Salt, Sulfamag
What is the mechanism of action of Magnesium Sulfate
Blocks Calcium Channels and serves as a bronchodilator . Smooth muscle relaxer
What drug class is Magnesium Sulfate
Mineral/Electrolyte, Antidysrhythmic
Indications for Magnesium Sulfate
Torsades de pointes
Asthma
Hypertension caused in pregnancy
Contraindications for Magnesium Sulfate
Shock
Dialysis (Renal Failure)
High Degree Heart Block
Hypocalcemia
V-Fib
Pulseless V-Tach in adults
Hypersensitivity
Common side effects of Magnesium Sulfate
Flushing, Sweating, bradycardia, Respiratory Depression, Hypothermia
Key drug/drug interactions of Magnesium Sulfate
Digitalis: Cardiac Conduction Problems
Calcium: Antidote to overdose
What is the adult dose of Magnesium Sulfate
1-2g for the tors, 2-4g for the whores
What is the pediatric dose of Magnesium Sulfate
25 mg/kg Max 2g
Is Magnesium Sulfate a standing order or only administered under medical direction?
Standing Order Unless:
Pre-Eclampsia or Eclampsia
Maintenance drip
What is the trade name of Furosemide
Furosemide
What is the mechanism of action of FurosemideIncreases excretion of water and electrolytes while blocking cotransport of sodium and chloride. This causes the proximal tubule, distal tubule, and thick descending loop of Henle to be unable to reabsorb either.
What drug class is Furosemide
Loop Diuretic
Indications for Furosemide
Acute Pulmonary Edema
Hyperkalemia
Congestive Heart Failure
Contraindications for Furosemide
Hypokalemia
Renal Shutdown
Hypovolemia, Dehydration, and hypotension
Pregnancy
Common side effects of Furosemide
Blurred vision, diarrhea, numbness, tingling, constipation, hypovolemia, hypotension, hyponatremia, and hypokalemia
Key drug/drug interactions of Furosemide
Salmeterol, Albuterol, : May cause hypokalemia
Esomeprazole: May cause hypomagnesemia
Metoprolol: Hypotension and Bradycardia
Insulin: May diminish effectiveness
Empagliflozin: Increases effect of Furosemide
What is the adult dose of Furosemide
Prior prescription of furosemide: 20 mg IV
No prior prescription of furosemide: 40 mg IV
What is the pediatric dose of Furosemide
Pediatric Dosage
Not indicated
Is Furosemide a standing order or only administered under medical direction?
Standing order unless:
Attempting use on a pediatric patient
What is the trade name of Dopamine
Intropin
What is the mechanism of action of Dopamine
Adrenergic agonist for Alpha and Beta receptors, raising rate and the contractility of the heart
What drug class is Dopamine
Sympathetic agonist
Indications for Dopamine
Hypotension
Contraindications for Dopamine
Hypovolemic Shock, Tachyarrhythmia, VFib
Common side effects of Dopamine
Palpitations, Anxiety, Hypertension, Headache, Dizziness, Worsened Cardiac Ischemia, Bradycardia, Dyspnea
Key drug/drug interactions of Dopamine
Alkaline Solutions: Will render the dopamine inactive
What is the adult dose of Dopamine
2-20 mcg/kg/min (1600)
What is the pediatric dose of Dopamine
2-20 mcg/kg/min
Is Dopamine a standing order or only administered under medical direction?
Standing Order Unless:
Pediatric Usage
What is the trade name of TXA
Cyklokapron, Lysteda
What is the mechanism of action of TXA
prevents plasmogin from converting into plasmin by binding to fibrin, reducing bleeding.
What drug class is TXA
antifibrinolytics
Indications for TXA
prevention/Reduction of hemorrhage
Contraindications for TXA
hypersensitivity
Thrombotic disorders
Subarachnoid hemorrhage
Intravascular clotting
Injury > 3 hours old
Common side effects of TXA
Hypotension, Thromboembolism, visual changes, nausea, vomiting, headache, dizziness, seizures, anaphylaxis
Key drug/drug interactions of TXA
Contraceptives: Increased risk of thrombosis
Clotting factors: increases risk of thrombosis
Thrombolytic agents: Lowers effectiveness
Trans Retinonic acids: Increases effect
What is the adult dose of TXA
10 mg/kg or 1g in 100ml NS over 10 minutes
What is the pediatric dose of TXA
10 mg/kg or 1g in 100ml NS over 10 minutes
Is TXA a standing order or only administered under medical direction?
Standing Order Unless
pediatric use
What is the trade name of Oxytocin
Oxytocin
What is the mechanism of action of Oxytocin
Induces contractions of smooth muscle in the uterus and has vasopressin/antidiuretic effects
What drug class is Oxytocin
Hormone
Indications for Oxytocin
Control of postpartum bleeding
Contraindications for Oxytocin
Hypersensitivity, Nonvaginal delivery oncoming or anticipated
Common side effects of Oxytocin
Hypotension, Hyponatremia, Painful Contractions, Abruptio Placenta, Uterine Motility, Seizure, Coma, Intracranial Hemorrhage
(Fetal: Arrhythmia, Asphyxia)
Key drug/drug interactions of Oxytocin
Vasopressors: Hypertension
What is the adult dose of Oxytocin
10 units in 500ml NS over 30 min
Is Oxytocin a standing order or only administered under medical direction?
Standing order
What is the mechanism of action of Heparin
Potentiates antithrombin and prevents conversion of prothrombin to thrombin
What drug class is Heparin
Anticoagulant
Indications for Heparin
Thromboembolic disorders
IV catheter maintenance
Contraindications for Heparin
Hypersensitivity
Uncontrolled bleeding
Thrombocytopenia
Premature infants
Common side effects of Heparin
Rash, urticaria, Hyperkalemia, Bleeding, Fever
Key drug/drug interactions of Heparin
Platelet affecting drugs: Risk of bleeding
Thrombolytics: Increased risk of breathing
Digoxin, Tetracyclines, Nicotine, Antihistamine: lowers effects
What is the adult dose of Heparin
60 units/kg up to 10000
What is the pediatric dose of Heparin
50-100 units/kg
Is Heparin a standing order or only administered under medical direction?
Medical direction
What is the trade name of Norepinephrine
Levophed
What is the mechanism of action of Norepinephrine
Stimulates alpha-adrenergic receptors in blood vessels causing vasoconstriction
What drug class is Norepinephrine
Vasopressor
Indications for Norepinephrine
Hypotension
Contraindications for Norepinephrine
Hypersensitivity
Tachy-dysrhythmias
Hypovolemia
Common side effects of Norepinephrine
Arrhythmias, Bradycardia, Chest pain, Hypertension, Hyperglycemia, Metabolic acidosis, Anxiety, Dizziness, Dyspnea, Fever, Tremor
Key drug/drug interactions of Norepinephrine
Digoxin, Doxapram, Anesthesia, Cocaine, Cyclopropane: Myocardial Irritability
Tricyclic antidepressants, MAO inhibitors, Doxapram: Hypertension
Beta blockers: Hypertension
What is the adult dose of Norepinephrine
2-4 mg in 500 mL NS
What is the pediatric dose of Norepinephrine
0.1 mcg/kg/min
Is Norepinephrine a standing order or only administered under medical direction?
Standing order unless used with a pediatric
What is the trade name of Nitroglycerin
Nitrostat, Tridil
What is the mechanism of action of Nitroglycerin
Converts into nitric oxide in the body to induce smooth muscle relaxation
What drug class is Nitroglycerin
Nitrate
Indications for Nitroglycerin
Angina
Heart Failure
Acute Myocardial Infarction
Pulmonary edema
Food impaction
Contraindications for Nitroglycerin
Systolic <90
Hypersensitivity
Anemia
Increased ICP
Hypovolemic Shock
Pericardial Tamponade
Common side effects of Nitroglycerin
Hypotension, Syncope, Tachycardia, nausea, vomiting, blurred vision, dizziness, Headache, Weakness
Key drug/drug interactions of Nitroglycerin
Afil suffix: Severe hypotension
ED medications: Severe hypotension
Anticholinergic drugs: Decreases absorption
Beta Blockers, alcohol, Calcium Channel blockers: Severe hypotension
What is the adult dose of Nitroglycerin
0.4 mg up to 3 times, max dose 0.15 mg
Is Nitroglycerin a standing order or only administered under medical direction?
Standing Order Unless:
Food impaction
Pediatric
>3 doses
What is the trade name of Aspirin
Ectotrin, Acuprin, Empirin
What is the mechanism of action of Aspirin
Inhibits prostaglandin production resulting in reduced inflammation and decreases platelet aggregation
What drug class is Aspirin
NSAID, Antiplatelet agent
Indications for Aspirin
Arthritis
Pain
Fever
TIAs and MIs
Contraindications for Aspirin
GI bleed within 7 days
Hypersensitivity
Bleeding disorders
Thrombocytopenia
Pediatrics
Pregnancy post 30 weeks
Common side effects of Aspirin
GI bleeding, dyspepsia, pain, nausea, anemia, rash
Key drug/drug interactions of Aspirin
Other NSAIDs: GI Upset
Blood Thinners: Increased Risk of Bleeding
What is the adult dose of Aspirin
324 mg (x4 81 mg tablets)
What is the pediatric dose of Aspirin
3-10 mg/kg
Is Aspirin a standing order or only administered under medical direction?
Standing Order
What is the trade name of Amiodarone
Cordarone
What is the mechanism of action of Amiodarone
Blocks alpha and beta receptors and keeps potassium from repolarizing the heart, lengthening the action potential
What drug class is Amiodarone
Anti-arrhythmic
Indications for Amiodarone
Pulseless ventricular tachycardia
Shock refractory ventricular fibrillation
Wide complex tachycardia with pulse
Contraindications for Amiodarone
Hypersensitivity, Bradycardia, Breastfeeding, Heart Block, Cardiogenic Shock
Common side effects of Amiodarone
Hypotension, Bradycardia, Prolonged PR, Prolonged QT, Prolonged QRS, Dizziness, Fatigue, Myoclonus, CHF
Key drug/drug interactions of Amiodarone
Grapefruit: Increases risk of negative effects
Any QT prolonging medications like Furosemide or Benadryl
Protease inhibitors: Prevents metabolism
Anticoagulants: Severe bleeding
What is the adult dose of Amiodarone
VF/VT Pulseless: 300mg IVP/IO repeated a max of 2 times 150 mg second dose
Post conversion with arrhythmia or increased ectopy: 150mgs in 100ml NS at 15mg/min over 10 minutes
Wide complex tachycardia: 150 mg/kg IV/IO in 100ml NS at 15mg/min over 10 minutes (MD)
What is the pediatric dose of Amiodarone
VF/VT Pulseless: 5 mg/kg up to 300mg per dose. May be repeated 2 times IV/IO. (MD)
Wide complex tachycardia: 5 mg/kg up to 150 mg per dose. May repeat once IV/IO. (Use 100ml NS and 50 gtts/min) (MD)
Is Amiodarone a standing order or only administered under medical direction?
Standing Order Unless
Adult or pediatric wide complex tachycardia (VT included in adults)
What is the trade name of Adenosine
Adenocard
What is the mechanism of action of Adenosine
Causes potassium efflux and blocks Calcium channels, hyperpolarizing the heart and causing the AV node to slow conduction.
What drug class is Adenosine
Nucleoside
Indications for Adenosine
SVT
Contraindications for Adenosine
Heart Block, Bronchospasm, Afib, Hypersensitivity, Heart Block, Torsades de Pointes
Common side effects of Adenosine
Dizziness, Nausea, Headache, Chest Pain, Flush
Key drug/drug interactions of Adenosine
Methylxanthines: Antagonist
Carbamazepine, Dipyridamole: Enhances effects
What is the adult dose of Adenosine
6 mg IVP, Can be repeated once with a dose of 12 mg if necessary.
What is the pediatric dose of Adenosine
0.1-0.2 mg/kg IVP
Is Adenosine a standing order or only administered under medical direction?
Standing Order Unless:
Pediatric use
What is the trade name of Diltiazem
Cardizem
What is the mechanism of action of Diltiazem
Blocks calcium channels to cause smooth muscle relaxation and AV node conduction. Lowers Blood pressure.
What drug class is Diltiazem
Anti-arrhythmic, Calcium Channel Blocker
Indications for Diltiazem
Narrow complex tachyarrhythmias (Stable)
Afib induced rapid ventricular rate
Contraindications for Diltiazem
Hypotension, CHF, Wide complex V-Tach, Cardiogenic Shock, Edema, Bradycardia, MI
Common side effects of Diltiazem
Nausea, Hypotension, Vomiting, Dizziness
Key drug/drug interactions of Diltiazem
Beta Blockers: BradyArrhythmias
Anticoagulants: Increased risk of bleeding
Metoprolol: Increases effects
What is the adult dose of Diltiazem
0.25 mg/kg max dose 20 mg over 2 minutes via IV bolus. May repeat once at an adjusted dose of 0.35 mg/kg after 10-15 min.
Is Diltiazem a standing order or only administered under medical direction?
Standing Order