Paracoccidioidomycosis Flashcards
Epidemiology of cases?
Most cases below 30yrs, mostly in males
What is the transmission?
Respiratory route, primary lung lesion sometimes through direct skin contact
How does juvenile parracocy present?
Lymphadenopathy, hepatoslpenomegaly, pancytopenia
What are the two main strains of paracoccy?
P. Brasiliensis
P. Lutzii
What is the main agent?
Paracoccidioides Braziliensis
This is a dimorphic fungus
What are the clinical forms of parracocy
Asymptomatic infection
Or Progressive forms: acute/subacture or juvenile form, chronic or adult type is unifocal or multifocal
What does acute form of disease look like?
Much less common
mean age 22
Rapid onset
Negative skin test
Fever, hepatospleonmegaly, skin and lymphadenopathy
What is the chronic form look like?
Older patients, much more slow growing
Positive skin test
Lung involvement
How does chronic adult multiform look?
Oral ulcers painful ++, infiltrate gums and teeth
Lymphadenopathy
Bilateral pulmonary infiltrates, usually sparing apex and lower lung fields
How does acute juvenile form look?
Skin lesions, on face Predominantly
Significant hepatospleonmegaly
Jaundice common
What is the pulmonary involvement?
Cavitary Lesions and pleural effusions less common
Bilateral infiltrates, sparing apex and bases
What is skin and muscosal form?
50% of patients develop muscosal Lesions- destructive and painful often causing tooth loss
Granulation with haemorrhagic dots
Classical of the chronic form
Skin lesions are less common in the chronic form
What does cutaneous involvement look like in juvenile form?
Paupules, pustules, nodules
Painful
Typically the face
What is CNS involvement in parracocy?
Hypodense focal lesions
More common in chronic form
What type of parracocy do HIV patients get?
Both acute and chronic form
Skin test is usually negative
High fatality
