paracetamol overdose

Question 1

what is the real name of paracetamol

Answer 1

acetaminophen

Question 2

mechanism

Answer 2

-overdose= overwhelmed liver
-NAPQI (N-acetyl-p-benzoquinomimined toxin released
-usually liver neutralized NAPQI with glutathione
-when overdosed glutathione store becomes depleated
-NAPQI builds up and causes oxidatitive stress to liver cells

Question 3

liver damage

Answer 3

NAPQI accumulates and attaches to hepatocytes and causes cells disruption
-the liver cant filter other substances so toxins build up

Question 4

symptoms

Answer 4

nausea, vomiting, general malaise
-jaundice,abdomial pain, confusion , swelling
-could lead to liver failure, bleeding and multiorgan failure

Question 5

treatment

Answer 5

-NAC (n-acetylcysteein) which replenashes gluthione levels and neutralises NAPQI
If caught every enough liver can fully recover
-3 doses over 21 hours IV

Question 6

source

Answer 6

Davis et at, 1976