Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Womens Health > Papsmear cytology and cervical/vaginal cytologic ds > Flashcards

Papsmear cytology and cervical/vaginal cytologic ds Flashcards

1
Q

pap results show:

A

Negative for Intraepithelial Lesion or Malignancy

No Neoplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what does Negative for Intraepithelial Lesion or Malignancy
(No Neoplasia)
mean?

A

Normal Pap Smear
Reactive cellular changes with inflammation, cellular repair, changes associated with IUD, Bacterial Vaginosis, Trichomoniasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

management of negative for Intraepithelial Lesion or Malignancy
(No Neoplasia)

A

No HPV → Follow routine PAP screening

If > 25yrs & HPV + → 2 options:
Cytology & HPV testing in 12 months OR Genotype for HPV 16, 18

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what are types of squamous cell abnormalities?

A

1) ASC-US: Atypical Squamous Cells of Undetermined Significance
2) ASC - H → Atypical Squamous Cells Can’t Exclude HSIL
3) LSIL → Low Grade Squamous Intraepithelial Lesion
4) HSIL → High Grade Squamous Intraepithelial Lesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what does ASC-US mean?

A

May be due to multiple reasons → Main goal is to see if HPV related or not
70% of ASC-US regresses @ 24 months but HPV+ lesions have higher risk of progression to carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

tx of ASC-US if older than 25?

A

HPV testing or repeat PAP:

HPV Negative → Repeat PAP & HPV cotesting in 3 yrs

HPV Positive → Colposcopy with Biopsy

Repeat PAP in 1 yr → If negative resume PAP screening
Colposcopy if positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

tx of ASC-US if 21-24 yo?

A

(includes LSIL) repeat pap in 1 yr or HPV test

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

tx of ASC-US if younger than 21

A

repeat pap in 1 yr

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what does ASC-H mean?

A

higher chance of cancer than ASC-US

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

tx of ASC-H?

A

colposcopy; Allows for visualization of the cervix using magnification after applying dilute acetic acid for accentuation of lesions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what does LSIL mean?

A

Most commonly associated w/ cellular changes seen w/ transient HPV infxn

Includes CIN I

50% regress in 24 mos → May progress to cancer in 7 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

tx of LSIL age 25-29?

A

Colposcopy with Biopsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

tx of LSIL > 30 yo?

A

HPV Negative → Repeat Cytology in 1 year

HPV Positive → Colposcopy with Biopsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what does HSIL mean?

A

Includes CIN II, CIN III & Carcinoma in situ

*usually from presisten HPV infxn : P-16 positive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

tx of HSIL?

A

colposcopy with Biopsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

types of glandular cell abnormalities?

A

1) atypical
2) atypical glandular cells favor neoplastic (Features suggestive but not sufficient for diagnosis of adenocarcinoma)
3) endocervial carcinoma in situ/adenocarcinoma/ endometrial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

management of all glandula cell abnormalities?

A

Colposcopy for all glandular cell abnormalities

Glandular abnormalities may be indicative of endometrial neoplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what is CIN?

A

cervical intraepithelial neoplasia

*precursor for cervical carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what is the transformation zone?

A

squamocolumnar junction of the cervix: HIGHEST RISK for malignancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

description of CIN I?

A

ellular changes seen with HPV

CIN I → MILD dysplasia → Contained to basal ⅓ of epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

describe CIN II

A

moderate dysplasia

Including ⅔ thickness of basal epithelium

22
Q

describe CIN III?

A

SEVERE dysplasia → >⅔ -up to full thickness of basal epithelium

23
Q

what is Carcinoma in situ?

A

full thickness of basal epithelium

has not invaded the basement membrane

Preinvasive Cancer

24
Q

tx options for CIN I?

A

observation: 75% resolve by immune system within 1 year
May be option if < 20 yrs

Excision:
LEEP → Loop Electrical Excision Procedure
Cold Knife Cervical Conization
+ Ablation

25
tx options for CIN 2&3?
excision or ablation
26
types of excision?
LEEP → Loop Electrical Excision Procedure Cold Knife Cervical Colonization
27
ablation types?
Energy-assisted destruction of lesions via: Cryocautery Laser Cautery Electrocautery
28
when to start screening for cervical cancer?
21 yo
29
when do you stop screening for cervical cancer?
65
30
how often are you screened?
age 21-29: every 3 yrs > 30 yo: cotesting--> Pap test & HPV q5 years preferred OR Pap every 3 years
31
what HPV are most commonly associated with cervical carcinoma?
Especially 16, 18 (70%), 31 & 33, 45, 52 & 58
32
avg age of dx for cervical cancer?
45 yo
33
where are the MC Mets for cervical cancer
Vagina, Parametrium, Pelvic Lymph Nodes
34
RF for cervical ca?
HPV, early onset of sexual activity, increased # of partners, smoking, CIN, DES exposure (Diethylstilbestrol = Synthetic Estrogen used in OCPs), Immunosuppression, STIs
35
what are the 2 types of cervical cancer?
Squamous (90%) | Adenocarcinoma (10%) → Clear cell carcinoma linked with DES
36
sx of cervical ca?
POST-COITAL BLEEDING/SPOTTING → Most Common Sx Metrorrhagia, Pelvic pain + Watery discharge
37
dx of cervical cancer
Colposcopy with Biopsy → Pap smear with cytology used for screening
38
what is stage 0 cervical cancer?
carcinoma in situ
39
how is stage 0 ca tx?
Local Treatment: Excision → LEEP, COld Knife Conization → Preferred Ablation → Cryotherapy, laser TAH-BSO
40
stage 1a1 ca?
microinvasion
41
tx of microinvasion?
Surgery → Conization, TAH-BSO, XRT
42
tx of stage I, IIA?
TAH-BSO, XRT + Chemo Tx → Cisplatin
43
definition of Stage IIb-IVa?
II → Extends Locally Beyond Cervix III → Lower ⅓ of vagina IVa → Local METS → Bladder, Rectum
44
stage IIb-IVa
XRT + Chemo → Cisplatin + 5FU
45
IVb or recurrent?
Metastatic: | IVb → Distant METS
46
tx of metastatic?
chemo, palliative SRT
47
how can cervical ca be prevented?
gardasil
48
whatis the gardasil recommendation?
Recommendations → Given at age 11 up to 26 years of age → 2 types Gardasil → Quadrivalent HPV Vaccine that targets HPV 6, 11, 16, 18 Gardasil 9 → Targets the same as Gardasil as well as HPV types 31, 33, 45, 52 & 58
49
what is the gardasil schedule?
Individual < 15 yrs should receive 2 doses of HPV vaccine at least 6 months apart > 15 yrs should receive 3 doses over a minimum of 6 months → Classically administered at day 0, 2 months and 6 months Minimum interval between 1st 2 doses = 4 wks Minimum interval between 2nd and 3rd doses = 12 wks
50
what are contraindications for gardasil?
Immunosuppressed, pregnant or lactating

Womens Health (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions