Pancreas Lecture

Question 1

Second largest gland

Answer 1

Pancreas

Question 2

T/F Pancreas is an accessory digestive gland

Answer 2

T

Question 3

T/F Pancreas is similar to salivary gland

Answer 3

T

Question 4

T/F Pancreas has exocrine and endocrine fxns

Answer 4

T

Question 5

Pancreas is derived from

Answer 5

Endoderm

Question 6

What is the beginning of the duct system of the pancreas?

Answer 6

Centroacinar cells

–>Exocrine fxn

Question 7

What do acinar cells do in pancreas

Answer 7

Make, store, and release digestive enzymes

Question 8

What do centroacinar cells make

Answer 8

Bicarbonate rich buffer and water

Question 9

Acinar cells basal and apical sides

Answer 9

Basal has rich RER and basophilic

Apical has zymogen granules and acidophilic

Question 10

Why is bicarbonate important?

Answer 10

Regulates pH to help enzymes properly fxn

Question 11

What helps form centroacinar cells?

-Epithelium

Answer 11

Intercalated ducts extend into lumen of acinus and have flattened cuboidal epithelium.

Receieve secretions from acini

Question 12

What receives secretions from intercalated ducts

-epithelium

Answer 12

Intralobular ducts

-cuboidal epithelium

Question 13

What’s found between lobules w/n CT septae

Answer 13

Interlobular ducts

-Simple cuboidal epithelium or columna-size varies so epithelium does too

Question 14

3 major groups of enzymes secreated by pancreas

Answer 14

Proteases
Pancreatic lipases
Amylases

Question 15

Proteases

Answer 15

Does majority of protein digestion

Trypsin is major player. Trypsin inhibitor should be present because without, trypsin would digest everything and cause acute pancreatitis.

Question 16

Pancreatic lipase

Answer 16

Triglyceride

Can’t be directly absorbed so digested into 2 monoglycerides and 2 FA. Bile salts are needed

Question 17

Amylase

Answer 17

Breaks down starch

Question 18

What innervates the pancreas

Answer 18

X

Applies low level stimulus to secretion in response to anticipation of a meal

Question 19

CCK

Answer 19

Secreted by SI when fat detected
Cholecystokinin
“move the bile sac”.
Stimulates acinar cells to secrete large amounts of proteases and lipase and cause gallbladder to contract.

Question 20

Secretin

Answer 20

Secreted by SI
Causes pancreatic duct (centroacinar cells/intercalated ducts) to secrete water and bicarbonate to lower pH so pancreatic enzymes can fxn properly.

Question 21

Gastrin

Answer 21

Secreted by stomach

Stimulates pancreatic acinar cells to secrete digestive enzymes.

Question 22

Endocrine component of pancreas

Answer 22

Islet of Langerhans/pancreatic islets

Question 23

Cell types in pancreatic islets

Answer 23

alpha (glucagon)
beta (insulin)
PP (pancreatic polypeptide)
delta (somatostatin)

Question 24

Exocrine component of pancreas

Answer 24

Glandular acinus and duct system

Question 25

What structures secrete HCO3 in pancreas

Answer 25

Intercalated ducts

Centroacinar cells