Pancreas and Hormones Flashcards
Major regulatory organ of glucose (both an exocrine & endocrine)
Pancreas
The exocrine gland produce and secretes
Amylase
Breaks down polysaccharide by destroying the glycosidic linkages
Amylase
Considered as the smallest enzyme enabling it to pass through the glomerulus to be NORMALLY excreted in the urine
Amylase
the EARLIEST pancreatic marker
Amylase
Isoenzyme of amylase produced by salivary gland
S-type (Ptyalin)
Isoenzyme of amylase produced by the acinar cells of pancrease
P-type (Amylopsin)
The endocrine gland secretes
Insulin (beta cells)
Glucagon (Alpha)
Somatostatin (delta cells of Langerhans)
Insulin, glucagon and somatostatin are produced by the
Pancreas (Islet of Langerhans)
Primary hormone responsible for the
entry of glucose into the cell (liver,
muscle, & adipose tissue) This action is done by enhancing the permeability of the cell to glucose
Insulin
Insulin promotes
Glycogenesis, Lipogenesis, & Glycolysis
Insulin decreases
Glycogenolysis
T/F: Serum Insulin: sample must be free from
hemolysis to prevent falsely decreased
result (due to the presence of Insulin Degrading Enzymes in RBC)
TRUE
Effects of insulin in glucose
Decrease
PRIMARY Hyperglycemic agent
Prevents cellular uptake of glucose
(prevents entry of glucose in contrast
with insulin)
Glucagon
Glucagon promotes
Glycogenolysis & Gluconeogenesis
Reference Value of glucagon
20-50 pg/mL
Glucagon is release during
Stress and fasting state
Hormone that promotes Gluconeogenesis & Lipolysis
Glucocorticoids
Glucocorticoids decreases
Cellular entry of glucose
Glucocorticoids is produced by
Zona fasciculata of Adrenal Cortex
Examples are Dopamine, Epinephrine,
Norepinephrine
Catecholamines
Catecholamines promotes
Glycogenolysis & Lipolysis
Catecholamines decreases
Insulin secretion
Catecholamines are produced by
Chromaffin cells of Adrenal medulla
Promotes: Glycogenolysis & Glycolysis
Decreases: Cellular entry of glucose
Growth Hormones (Somatotropin)
GH is produce by
Anterior Pituitary Gland or Adenohypophysis
Glycogenolysis, Gluconeogenesis, Intestinal Absorption of Glucose
Thyroid hormone
Examples of thyroid hormone
-Triiodothyronine (T3)
-Thyroxine (T4)
- Actions to stimulate the release of cortisol by the adrenal cortex
- Cortisol is an example
Adrenocorticotropic Hormone (ACTH)
ACTH promotes
Glycogenolysis & Gluconeogenesis
ACTH is produce by
Anterior Pituitary Gland
Inhibits: Action of Insulin and/ or Glucagon
Somatostatin