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MRCP - Part 1 > Palliative Care > Flashcards

Palliative Care Flashcards

1
Q

What anti-emetic should be used when the patient is hypercalcaemic?

A

Haloperidol

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2
Q

Which cytotoxic agent is most likely to have cardiomyopathy as a dose dependent side effect?

A

Doxorubicin

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3
Q

Intitial morphine prescription in palliative care

A

Slow release morphine 15mg BD
Plus top up morphine

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4
Q

What is the most aggressive primary tumour of the thyroid gland

A

Anaplastic carcinoma of the thyroid

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5
Q

Management in opiate induced constipation

A

Senna
Docusate
Lactulose

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6
Q

What can provide a survival benefit in MND

A

NIV
Riluzole

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7
Q

Where does a gliblastoma multiforme must commonly occur

A

Subcortical white matter of the cerebral hemispheres

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8
Q

Who does the gold standards framework identify

A

Patients with life limiting conditions

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9
Q

What is fentanyl a well known cause of

A

Itching
Sweating
Rash

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10
Q

if a fentany patch is 25ug/hr - how much morphine does this equate to in a day roughly

A

60-164mg

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11
Q

Is fentanyl safe in kidney impairment

A

yes

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12
Q

Does cyclizine lead to prolonged QTc?

A

No

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13
Q

Dose conversion from oral to s/c morphine

A

50%

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14
Q

Oral morphine to s/c diamorphine conversion

A

Divide by 3

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15
Q

What anti emetic acts via neurokinin 1 receptor

A

Aprepitant

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16
Q

Is fentanyl accumulated in the kidneys

A

No

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17
Q

Mechanism of action of lorazepam

A

GABA A modulation

18
Q

What can belomycin (chemotherapy agent) commonly cause

A

Pulmonary toxicity

19
Q

Poor prognosis factors for breast cancer

A

High grade tumour
Oestrogen receptor negative tumour
Progesterone receptor negative tumour
Young age < 40
Premenopausal at diagnosis
Increased tumour size

20
Q

What can improve pain from a pancreatic cancer / chronic pancreatitis pain when not controlled with adequate oral analgesia

A

Coeliac plexus block

21
Q

PS0

A

Fully active, able to carry on all predisease performance without restriction

22
Q

PS1

A

Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g. light housework, office work

23
Q

PS2

A

Ambulatory and capable of all self care but unable to carry out any work activities
Up and about more than 50% of the waking hours

24
Q

PS3

A

Capable of limited self care
Confined to bed or chair > 50% waking hours

25
Q

PS4

A

Comlpetely disabled, cannot perform any self care, totally confined to a bed or chair

26
Q

Mechanism of action of baclofen

A

Gamma aminobutyric acid B receptor agonist

27
Q

Treatment ladder for carcinoid syndrome symptoms

A
  1. Octreotide
  2. Telotristat
  3. interferon alpha
  4. radionucleotide therapy
28
Q

Features of Li-Fraumeni syndrome

A

AD inheritance

Bone and soft tissue sarcomas
Breast ca

29
Q

Genetics of Li-Fraumeni syndrome

A

TP53

30
Q

Assosiations of BRAC2 mutation

A

Breast cancer
Ovarian
Pancreatic cancer
Prostate cancer

31
Q

How to divide codeine to morphine dose

A

Divide by 10

32
Q

Monitoring of testicular teratomas

A

AFP

33
Q

WHat tymour marker is useful to monitor for metastatic disease secondary to breast cancer

A

CA 15-3

34
Q

Treatment of oculogyric crisis secondary to metoclopramide

A

Benztropine

35
Q

Risk factors for bladder cancer

A

Smoking
Exposure to coal, tar and asphalt
Working in the chemical or plastics industries
Exposure to drugs such as cyclophosphamide

36
Q

translocation of chromosomes in Burkitts lymphoma

A

t(8;14)(q24;q32)

37
Q

Antibodies of lambert eaton myasthenic syndrome

A

Presynaptic voltage gated calcium channel antibodies

38
Q

The risk of which cancer is reduced by taking the OCP

A

Colon cancer

39
Q

Gene mutation of HNPCC

A

MLH1 gene

40
Q

Another name for HNPCC

A

Lynch syndrome

41
Q

Features of HNPCC

A

Colon cancers seen as early as 5th dease
Uterine cancers around 60 y/o
Screening upper and lower GI endoscopies recommended from 20 y/o

42
Q

Monitoring for papillary thyroid cancer recurrence

A

Thyroglobulin

MRCP - Part 1 (20 decks)

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