Palliative Care

Question 1

What anti-emetic should be used when the patient is hypercalcaemic?

Answer 1

Haloperidol

Question 2

Which cytotoxic agent is most likely to have cardiomyopathy as a dose dependent side effect?

Answer 2

Doxorubicin

Question 3

Intitial morphine prescription in palliative care

Answer 3

Slow release morphine 15mg BD
Plus top up morphine

Question 4

What is the most aggressive primary tumour of the thyroid gland

Answer 4

Anaplastic carcinoma of the thyroid

Question 5

Management in opiate induced constipation

Answer 5

Senna
Docusate
Lactulose

Question 6

What can provide a survival benefit in MND

Answer 6

NIV
Riluzole

Question 7

Where does a gliblastoma multiforme must commonly occur

Answer 7

Subcortical white matter of the cerebral hemispheres

Question 8

Who does the gold standards framework identify

Answer 8

Patients with life limiting conditions

Question 9

What is fentanyl a well known cause of

Answer 9

Itching
Sweating
Rash

Question 10

if a fentany patch is 25ug/hr - how much morphine does this equate to in a day roughly

Answer 10

60-164mg

Question 11

Is fentanyl safe in kidney impairment

Answer 11

yes

Question 12

Does cyclizine lead to prolonged QTc?

Answer 12

No

Question 13

Dose conversion from oral to s/c morphine

Answer 13

50%

Question 14

Oral morphine to s/c diamorphine conversion

Answer 14

Divide by 3

Question 15

What anti emetic acts via neurokinin 1 receptor

Answer 15

Aprepitant

Question 16

Is fentanyl accumulated in the kidneys

Answer 16

No

Question 17

Mechanism of action of lorazepam

Answer 17

GABA A modulation

Question 18

What can belomycin (chemotherapy agent) commonly cause

Answer 18

Pulmonary toxicity

Question 19

Poor prognosis factors for breast cancer

Answer 19

High grade tumour
Oestrogen receptor negative tumour
Progesterone receptor negative tumour
Young age < 40
Premenopausal at diagnosis
Increased tumour size

Question 20

What can improve pain from a pancreatic cancer / chronic pancreatitis pain when not controlled with adequate oral analgesia

Answer 20

Coeliac plexus block

Question 21

PS0

Answer 21

Fully active, able to carry on all predisease performance without restriction

Question 22

PS1

Answer 22

Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g. light housework, office work

Question 23

PS2

Answer 23

Ambulatory and capable of all self care but unable to carry out any work activities
Up and about more than 50% of the waking hours

Question 24

PS3

Answer 24

Capable of limited self care
Confined to bed or chair > 50% waking hours

Question 25

PS4

Answer 25

Comlpetely disabled, cannot perform any self care, totally confined to a bed or chair

Question 26

Mechanism of action of baclofen

Answer 26

Gamma aminobutyric acid B receptor agonist

Question 27

Treatment ladder for carcinoid syndrome symptoms

Answer 27

1. Octreotide
2. Telotristat
3. interferon alpha
4. radionucleotide therapy

Question 28

Features of Li-Fraumeni syndrome

Answer 28

AD inheritance

Bone and soft tissue sarcomas
Breast ca

Question 29

Genetics of Li-Fraumeni syndrome

Answer 29

TP53