Palliative Care Flashcards

1
Q

o Starting doses for oromorph?

A

2.5-5mg, 4-hourly

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2
Q

if pain not 90% relieved, how much should the dose be increased by?

A

o Increase by 1/3rd (30-50%)

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3
Q

o Breakthrough doses of morphine should be what?

A

= 1/6th of total morphine in 24 hours

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4
Q

Bony metastasis pain:

A

1st: Analgesia
2nd: Bisphosphonates
3rd: Radiotherapy

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5
Q
  • Immediate release morphine formualations: (IR; ≤4 hours):
A

o Oromorph (liquid)
o Sevredol (tablet)
o Morphine injection

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6
Q
  • Modified release morphine (MR):
A

o MST / zomorph (BD)
o MXL (OD)

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7
Q

Metoclopramide - avoid in which patients?

A
  • Avoid in Parkinson’s (DA antagonist) – use domperidone (does not cross BBB)
  • Avoid in young women (risk of dyskinesia i.e. acute dystonia)
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8
Q

Which anti-emetic to prescribe in fluid retention?

A

Metoclopramide, avoid cyclizine

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9
Q

Vestibular N&V drug choice?

A

Cyclizine

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10
Q

Raised ICP N&V drug choice?

A

Cyclizine (± dexamethasone)

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11
Q

Chemical N&V drug choice?

A

Ondansetron, haloperidol, levomepromazine

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12
Q

Which drug for chemotherapy nausea?

A

Ondansetron

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13
Q

Gastric stasis N&V drug choice?

A

Metoclopramide (CI: BO), domperidone

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14
Q

Constipation, oral candidiasis N&V drug choice?

A

Cyclizine, levomepromazine

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15
Q

Anxiety, pain, fear, anticipatory nausea N&V drug choice?

A

BDZ (lorazepam), cyclizine

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16
Q

2nd line Mx for agitation/confusion?

A

o 2nd line: chlorpromazine, levomepromazine

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17
Q

Terminal restlessness treatment?

A

Midazolam (PRN SC injections or SC infusion by syringe driver)

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18
Q

Treatment for excess secretions?

A

o Medical:
1st line: hyoscine hydrobromide / butylbromide
2nd line: glycopyrronium bromide

19
Q

Hiccups mx in palliative care?

A
  • Management:
    o 1st line: chlorpromazine
    o 2nd line: haloperidol, gabapentin
    o Hepatic lesions: dexamethasone
20
Q

Treatments for neuropathic pain?

A

Amitriptyline, gabapentin, pregablin, duloxetine

21
Q

Which cancers are most likely to cause Bone metastases?

A

Precious bone killed through lesions
Prostate, breast, kidney, thyroid, lung

22
Q

Marker of bone degeneration?

A

ALP

23
Q

Most common histological prostate cancer?

A

Adenocarcinoma

24
Q

Tx for intermediate/high grade prostate cancer?

A

Radical prostectomy

25
Q

Types of breast cancer?

A

Ductal carcinoma in situ, lobular carincoma in situ, invasive ductal carcinoma, invasive lobular carcinoma, paget’s disease of the breast, inflammatory breast cancer

26
Q

Sites of metastasis in breast cancer?

A

Lung, liver, bone, brain, adrenals

27
Q

Treatment for HER2 positive breast cancer?

A

Herceptin

28
Q

ER/PR positive breast cancer treatments?

A

Pre-menopausal = tamoxifen
Post-menopausal = aromatase inhibitors: letrozole, anastrozole

29
Q

Small cell lung cancer buzzwords?

A

Cushing’s syndrome (ACTH production)
SIADH ( ADH production)

30
Q

Large cell lung cancer buzzwords?

A

Gynaecomastia

31
Q

Squamous cell lung carcinoma buzzwords?

A

Hypercalcaemia secondary to PTHrp production

32
Q

Adenocarcinoma of the lung buzzwords?

A

Low smoking risk, most common

33
Q

Tx for SVCO?

A

Give dexamethasone
Might need intubation
Diuretics
Endovascular stenting

34
Q

What is adjuvant chemotherapy?

A

Given AFTER surgery

35
Q

What is neo-adjuvant chemotherapy?

A

Given before surgery to help reduce the size of the tumour

36
Q

Tx for end of life breathlessness?

A

oral morphine, midazolam

37
Q

Conversion from oral to SC morphine?

A

x0.5

38
Q

Conversion from oral to SC diamorphine?

A

x0.33

39
Q

Conversion from morphine to tramadol?

A

x10

40
Q

Conversion from oral morphine to oral oxycodone?

A

x0.5

41
Q

Conversion from morphine to codeine?

A

x10

42
Q

Conversion from morphine to pethidine IV?

A

x2.5

43
Q

Conversion from morphine to fentanyl IV?

A

x0.005

44
Q
A