Pain treatments

Question 1

NSAIDs MOA

Answer 1

• inhibit prostaglandin release by inhibiting COX enzymes that produce it
• anti-inflammatory + analgesic effects

Question 2

Pregabalin class, indication + MOA

Answer 2

Gabapentinoids - neuropathic pain
- bind to A2 delta subunit on calcium channels
- decrease Ca influx into pre-synaptic neuron
- therefore decrease release of neurotransmitters

Question 3

Amitriptyline + Duloxetine class + MOA

Answer 3

Amitriptyline = TCAs
Duloxetine = SNRIs
- inhibition of synaptic noradrenaline + serotonin reuptake
- therefore strengthens pain modulation

Question 4

Opioids MOA

Answer 4

• agonists at mu receptor
• decrease adenylyl cyclase activity therefore decrease cellular activity in CNS
• therefore dampen pain

Question 5

THC class + effects

Answer 5

• partial antagonist at CB receptors
• increase sleep, decrease pain

Question 6

CBD class + effects

Answer 6

• antagonist at CB receptors
• manage seizures + pain
• decrease anxiety