Pain managment Flashcards
Metastatic cancer with bone pain treatment;
Parecetamol
NSAID i.e diclofinac, (if not contraindicated)
Opiods i.e moprhine
What are some nsaids?
Diclofinac, naproxen, celecoxib
many side effects
lots of contrindications
What are some opiods?
morphine, oxycodone, methadone
increase release of GABA (mu receptors)
Minor side effects
What are analgesics with novel actions?
•Amitriptyline•Gabapentin•Ketamine
What is Amitriptyline action
Serotonin and noradrenaline reuptake inhibition
increases endogenous opiods
What is gabapentin?
gaba analogue, though no gaba effects
Decreases Ca inwards flux
What is pain?
Physical and psyhological sensation i.e psyche can make it worse
Where do nsaids act?
Cyclooygenase inhibition
how does morphine function?
Increased GDP
increased GABA release