Pain And Hyperalgesia Flashcards
Mention areas with NO nociceptors
Brain, bone, liver parenchyma, lung alveoli,
Describe mechanism of stimulation of nociceptors
Tissue damage leads to accumulation of pain producing substances (kinin, potassium, histamine, substance P), which stimulate chemo-sensitive pain receptors & lower the threshold for stimulation of thermosensitive and mechanosensitive pain receptors.
Higher nervous perception site of pain is ….& its adaptability is …..
Thalamus & sensory cortex
Non-adapting (tonic receptors)
Causes of cutaneous pain
Injury/inflammation of skin
Irritation of dorsal roots
Referred pain to skin other diseased deep or visceral structure
Compare fast & slow cutaneous with respect to:
1.. summation
2. Receptors
3. Perception
F, no sum, mechano-&thero-sensitive pain receptors, sensory cortex
S, sum, all esp chemo, reticular formation, specific thalamic nuclei & tectum of midbrain
Fast pain fibers terminate on ….. in spinal cord, & in ….. in thalamus
Lamina marginalis
VPLN
Slow pain fibers ends on …. In spinal cord
Lamina II & III
Enumerate structures on which Most neurons of the paleospinothalamic pathway end
- Reticular nuclei of brain stem
- Tectal area of midbrain
- Periaqueductal gray region
Causes of deep pain
- Injury/inflammation of deep structures
- Ischemia/spasm of muscles
Causes of visceral pain
- Inflammation of peritoneal covering of viscera
- Irritation/ischemia of viscera
- Spasm/overdistention of viscera
Describe characters of visceral pain
The same characters of slow cutaneous pain
May lead to: depressor autonomic effects, rigidity of overlying skeletal muscle, referred to other structures.
Compare slow & fast pain with resoect to somatic, autonomic & emotional reactions
Fast: flexor withdrawal reflex occurs, symp activity, crying, restlessless & anxiety
Slow: rigidity of overlying muscle with deep & visceral pain, para, emotional depression & sadness
2ry hyperalgesia frequently results from ……
Lesions in the spinal cord or the thalamus
Compare primary & secondary hyperalgesia
1ry: inflamed skin around injury, facilitation of pain receptors by chemicals (substance P), non-painful stimulus becomes painful.
2ry: healthy skin, convergence-facilitation theory, painful stimulus becomes more painful
CP of Zoster
Severe pain followed within few days by a rash similar to that of varicellabut is unilateral and limited in distribution to the skin innervated by a DRG