PAIN

Question 1

Nociceptors

Answer 1

Respond to chemical mechanical and thermal stimuli

Question 2

Mechanonociceptors

Answer 2

Respond to stimulation, such as stretching, cutting or pressure

Question 3

Thermal Nociceptors

Answer 3

Respond to temperature stimulation, i.e hot or cold stimuli

Question 4

Chemical Nociceptors

Answer 4

Respond to chemicals and spices such as capsaicin, exogenous ligands and certain fatty acids

Question 5

Silent Nociceptors

Answer 5

Respond only to inflammation of the surrounding tissue post initial injury/insult

Question 6

A-delta fibre

Answer 6

• Medium-sized lightly myelinated axons with a conduction velocity of 2-30m/s
• Associated with acute/sharp pain, temperature and pressure (mechanonociceptors/mechanothermal nociceptors)
• Responsible for the ‘reflex arc’ response

Question 7

C-fibre

Answer 7

Small diameter, unmyelinated with a slow conduction velocity of no more then 2m/s
Polymodal: stimulated by mechanical, thermal and chemical receptors
Associated with dull, aching, burning sensations which are poorly localised

Question 8

A-beta fibres

Answer 8

• Large myelinated fires which transmit touch and vibration

- Does not transmit pain but play a role in pain modulation