Pain Flashcards
Discord between GCaMP and electrophysiological studies may arise from invasiveness of electrophysiology and trauma of dissociation
Smith, 2018
Cloning of capsaicin receptor via calcium influx
Caterina et al, 1997
TRMP3, TRPV1, TRPA1 involved in noxious heat sensing
Vadewauw et al, 2018
TRPM8 knockout mice = diminished cold response, but avoid surfaces <10°C
Bautista et al, 2007
TRPA1-dependent cold-induced nociceptive behaviour in mice
Karashima et al, 2009
Piezo1 required for mechanical currents; piezo2 knockdown reduces RA currents
Coste et al, 2010
Loss of piezo2 = impaired noxious mechanical response; optogenetic activation = nociception
Murthy et al, 2018
Evolutionary pressure for more profound acid-induced inhibition of Nav1.7 in naked mole rats
Smith et al, 2011
Mambalgin abolishes pain via inhibition of ASICs in central/peripheral neurones
Diochot et al, 2012
Neuropathic pain initiated by HCN2-driven AP firing in Nav1.8-expressing nociceptors
Emery et al, 2011
Epac1-Piezo2 axis has a role in the development of mechanical allodynia during neuropathic pain
Eijelkamp et al, 2013
Epac inhibitor reverses mechanical allodynia and loss of intraepidermal fibres in model of cheotherapy-induced peripheral neuropathy
Singhmar et al, 2018
Requirement for NaV 1.7 in regulating somatic (noxious heat pain threshold) but not in visceral pain signalling
Hockley et al, 2017
Engineered glutamate-gated chloride channel to silence sensory neurones and treat neuropathic pain
Weir et al, 2017
Cobra neurotoxin produces central analgesic and hyperalgesic actions via adenosine receptors
Chuang et al, 2017
Ipsilateral and contralateral localised vibratory stimulation modulated pain-related sensory thresholds
Doi et al, 2018
NMDA receptor activation underlies loss of spinal dorsal horn neurones and transition to persistent pain after peripheral nerve injury
Inquimbert et al, 2018
Temperature triggering behavioural and TRPA1 responses lower for shade-dwelling lizards
Akashi et al, 2018
Density of TRPA1 regulated by TRPV1; heteromerisation may change roperties
Akopian, 2011
TRPA1/V1 complex co-immunoprecipitated and interaction confirmed by TIRF FRET
Staruschenko et al, 2010
Cannabinoids desensitise capsiaicin and mustard oil responses in sensory neurones via TRPA1 activation
Akopian et al, 2008
Sporadic onset of erythermalgia (Nav1.7)
Rush et al, 2006
Nav1.8 in grasshopper mice defends against bark scorpion toxin
Rowe et al, 2013
Hypofunctional TrkA accounts for absence of pain sensitisation in naked mole rat
Omerbasic et al, 2016
