Invertebrate Phototransduction Flashcards
TRP activation by PLC
Hardie, 2011
Challenge to TRP activation by PLC
Montell, 2012
Protonophore (DNP) → ATP depletion opens channels
Montell, 2012
Activation equally effective with/without ATP in patch clamp; unaffected by oligomycin
Agam et al, 2004
PUFA-induced channel activity suppressed by mechanosensitive-channel inhibitor
Parnas et al
Ca2+ influx mediates 30% light-dependent current
Chu et al
Negative feedback on TRP/TRPL terminates quantum bumps and accounts for major features of light adaptation
Gu et al
Phototransduction in Drosophila depends on Ca2+-release mediated signalling; TRP is essential for the normal function of this process
Cook and Mink (1999)
Constitutive activity of TRP/TRPL in rdgA DAG kinase mutant; uncontrolled calcium influx leads to cytotoxicity
Raghu et al, 2000
Ca2+-dependent metarhodopsin inactivation mediated by calmodulin and NINAC myosin II
Liu et al, 2008
Ca2+ influx at rhabdomeres generates large-amplitude transient; dispersion of intracellular Ca2+ stores does not mimic/interfere with photoexcitation
Ranganathan et al, 1994
Functional cooperation between IP3 receptor and phospholipase C secures high sensitivity to light of Drosophila photoreceptors in vivo
Kohn et al, 2016
Phototransduction in Drosophila is compromised by Gal4 expression but not by IP3R knockdown or mutation
Bollepalli et al, 2017
PLCβ activated by Gqα; Gqα essential for activation of phototransduction cascade; manipulation of sensitivity by expression
Scott et al (1995)
Trp gene is essential for a light-activated Ca2+ channel in drosophila photoreceptors
Hardie and Minke (1992)
Activation of TRP channels by protons and phosphoinositide depletion in Drosophila photoreceptors
Huang et al, 2010
Regulation of Drosophila TRPL channels by PLC-dependent mechanisms
Estacion et al, 2004
inaD serves as scaffold to assemble components of phototransduction cascade
Tsunoda et al, 1997
Amplification requires activation of multiple G protein and PLC molecules; DGK = key enzyme regulating amplification; DAG implicated as messenger of excitation in Drosophila phototransduction
Hardie et al, 2002
Photolysis of caged Ca2+ facilitates and inactivates but does not directly excite light-sensitive channels in Drosophila photoreceptors
Hardie et al, 1995
Ectopic expression of mouse melanopsin in Drosophila photoreceptors
Yasin et al, 2017
Support for DAG as membrane-soluble messenger; PIP-depletion model cannot account for all results
Delgado et al, 2019
