Olfactory Transduction

Question 1

ORNs broadly tuned with low affinity for odorants, integrate stimulus information over time and have narrow dynamic range

Answer 1

Firestein et al (1993)

Question 2

Linear I-V relation over physiological range; odour at the cilia elicits larger response

Answer 2

Firestein et al (1990)

Question 3

NKCC1-mediated Cl- uptake counteracts Cl- depletion in cilia

Answer 3

Kaneko et al (2004)

Question 4

Cl- concentration obtained by energy-dispersive X-ray microanalysis and electron-scattering analysis

Answer 4

Reuter et al (1998)

Question 5

Na+-dependent extrusion governs response recovery in frog olfactory receptor cells; prolonged current from Ca2+-activated Cl- current

Answer 5

Reiset and Matthews (1998)

Question 6

Excitatory repetitive burst of spikes and inhibitory reduction in basal spike rate in response to prolonged odours

Answer 6

Reisert and Matthews (2001)

Question 7

Ca2+ binds CaM near CNG channels; inactivation of CNG near threshold for CACC

Answer 7

Bradley et al (2005)

Question 8

Desensitisation mediated upstream of cAMP production (odorant-induced current shows stronger decay than exogenous cAMP)

Answer 8

Takeuchi and Kurahashi (2002)

Question 9

Flash photolysis of caged cAMP activates 94% cells; response latency, rising time and duration shorter when flash localised at cilia

Answer 9

Lagostena and Menini (2003)

Question 10

Profound differences in kinetics and dynamic range between cells with samer receptor

Answer 10

Grosmaitre et al (2006)

Question 11

Lower amplification at cAMP stage may reduce loss of ATP; amplification at channels

Answer 11

Takeuchi and Kurahashi (2005)

Question 12

Second messenger molecules only work in the vicinity of their site of generation

Answer 12

Takeuchi and Kurahashi (2018)

Question 13

Antagonistic responses to mixtures with competitive antagonism allows encoding of all odours in a mixture

Answer 13

Reddy et al (2018)

Question 14

Negative modulation by Ca2+ via CaM on CNG channels underlies adaptation

Answer 14

Bradley et al (2001)

Question 15

Ca2+ reduces apparent affinity of channel for cAMP by up to 20-fold in presence of CaM

Answer 15

Chen and Yau (1994)