Pain Flashcards
Na+ channel blockers used for pain relief
Carbamazepine
Lamotrigine
Topiramate
Ca++ channel blockers used for pain relief
Gabapentin
Pregabalin
Na + channel blocker used for trigeminal neuralgia
Carbamazepine
What are the side effects of carbamazepine
Aplastic anemia
Also P4503A4 inducer
Na+ channel blocker with no FDA approval for pain and causes stevens johnson syndrome
Lamotrigine
Ca++ channel blocker used for DM neuropathy
Gabapentin
What are the side effects of Gabapentin
Weight gain
Sedation
Ca++ channel blocker used for DM neuropathy and fibromyalgia
Pregabalin
What are the side effects of pregabalin
Mild addiction
weight gain
sedation
Na++ channel blocker used for Migraines
Topiramate
What are the side effects of topiramate
Weight loss
Acidosis
Oligohydrosis
Glaucoma
What are the antidepressants used for pain?
Duloxetine and milnacipran–SNRIs
Amitriptyline–TCA
If descending NE projection is weak what occurs causing pain
NE release is less–so less of an inhibitor action of GABA–causing pain
NE normally stimulates GABA–which inhibits the pathway–inhibiting pain