Dementia

Question 1

Treatment for frontotemporal dementia

Answer 1

Divalproex for behavior control

SSRIs for irritability, depression, and impulsive behavior

Question 2

Treatment of AD

Answer 2

Cholingergic therapy–anticholinesterase

• Donepezil
• Rivastigmine
• Galantamine

–Increase ACh in synapse and slow progression of memory loss

NMDA receptor antagonists–Memantine
–excitability of neuron can cause damage in AD–so slow down that excitability with glutamate NMDA receptor blocker and decrease the neuronal damage

Question 3

Treatment of neuropsychiatric disturbances seen with AD

Answer 3

1st approach is counseling

Antipsychotics –atypicals–risperidone and haloperidol

Antidepressants–sertraline and venlafaxine

Anxiolytics–busprione and lorazepam

Question 4

Treatment of dementia with levy bodies

Answer 4

Cholinesterase inhibitors–may provide symptomatic support

AVOID antipsychotic drugs–will make parkinsonism sum worse

Treat REM sleep disorder with Clonazepam