Pain Flashcards
What is the dual nature of pain?
sensory: throbbing, prickly, hot, dull
emotional: torturing, annoying, frightful, sickening
What does pain regulation involve which variables such as osmolarity and blood pressure do not in order to maintain homeostasis?
requires physiology, behvaior & affective cognition to maintain
What are the two pathways that we can adapt to pain?
bottom-up pathway to control pain perception & top-down pathways to mediate emotion & reappraisal
What is the pain matrix made up of?
spinothalamic tracts and CNS- the regions for pain processing & regulation
The final experience of pain results from actions b/w what three orders of brain processing?
- nociceptive matrix
- perceptual/attentive matrix
- reapprasial/emotional matrix
What is the nociceptive matrix made up of?
ascending paths which go to the reticular formation , thalamus, amydala & somatosensory areas
What two structures of the brain make up the perceptual/attentive matrix?
anterior insula & cingulate cortex
What structure makes up the reapprasial/emotional matrix?
PFC
Which type of nociceptor neurons enter which lamina of dorsal horns?
Agamma goes to lamina I & V
C goes to lamina I & II
Lamina I neurons are mostly what type of pain receptors? They also respond to what?
nociceptors mostly; also respond to warm, cold, itch & other innocuous stimuli
Lamina V neurons respond to a narrow or wide range of pain stimulation?
wide dynamic range- signal pain intensity & mechanical stimuli; receive convergent info from Abeta, Agamma & C fibers
Axons of Lamin I & V decussate & form what pathway? Where does this pathway lead to?
anterolateral pain pathway to brain stem & thalamus
Dorsal horn neurons mediate what two types of pain?
fast & slow
Where do spinothalamic neurons project from and to?
from dorsal horn
up anterolateral column and to the posterior thalamus
The posterior thalamus projects pain input to where?
somatosensory cortex
posterior insula
cingulate cortex
Spinothalamic tracts branch into what? Where do each of these braches project to?
reticular formation nuclei: A5-7 (to cortex/spinal cord for attention & arousal), parabrachial (to amygdala) & periaqueductal gray (part of descending pathway that control sensitivity to pain)
Where does the perceptual matrix project to? What does it transform sensory events into?
anterior insula, anterior cingulate, PFC & posterior parietal cortex
transforms sensory events into vegtative reactions & internal feelings
In the perceptual matrix, the cingulate is the site of what and decides what?
site of affective/emotional aspects of pain
decides on behavioral patterns due to pain
In the perceptual matrix what does the insula integrate?
appetitive & aversive valence of pain w/impact it will have on body
