Pain Flashcards

1
Q

Definition of pain:

A

An unpleasant sensory and emotional experience associated
with actual or potential tissue damage

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2
Q

How is pain classified?

A

Primary: not associated with illnesses
-Tension headache -> Stress (chronic or episodic)
-Migraine headache (with or without aura)
-Cluster headache
-Medicinal overuse headache

Secondary: symptoms of a condition
-sinus/congestion, head trauma, stroke, substance withdrawal/abuse, bacterial/viral diseases, the disorder of craniofacial structure

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3
Q

Location of headaches:

A

-Sinus: behind eyebrows and cheekbones
-Cluster: in and around one eye
-Tension: like a band on the forehead
-Migraine: on one side of the face

-temporomandibular joint: on the side (temple)

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4
Q

Patient presentation of tension headache

A

-Bilateral
-Gradual onset
-diffuse -> tight, pressing, compressing pain
-minutes to days
-Triggers: stress, emotional imbalance (anxiety, depression,
etc), lack of sleep

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5
Q

Patient presentation for Migraine:

A

-Pain unilateral, throbbing, and more severe than a tension headache
-Sudden onset
-with or without aura
-hours to days
-symptoms: nausea, vomiting, constipation, diarrhea, lightheadedness, light/sound/movement
sens

to remember: SULTANS

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6
Q

Patient presentation for Sinus headache:

A
  • localized to the face, forehead, and periorbital areas
    -Onset simultaneous with nasal symptoms
    -Dull bilateral pain, pressure behind the eye or face
    -last days resolves with sinus symptoms
    -symptoms: nasal discharge; congestion, fever
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7
Q

Medication overuse:

A

-use of offending agent more than twice weekly
for ≥3 months
-Onset within hours of stopping agent
-Symptoms: continuous pain, upon awakening
-Potential causative agents: acetaminophen, aspirin, caffeine,
triptans, opioids, butalbital, and ergotamines

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8
Q

Pathophysiology of pain

A

Cell damage -> release of chemicals to depolarize nociceptors and prompt pain transmission

bradykinin, histamine, serotonin, prostaglandins,
potassium, substance P, calcitonin gene-related peptide
(CGRP)

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9
Q

When are patients referred? NO otc TREATMENT

A

-secondary headache except for sinus headache
-severe pain, severe symptoms (nausea, vomiting)
-a headache for more than 10 days
-severe infection (green/brown discharge, stiff neck)
- under 8 y of age
-significant liver problems or alcoholic consumption bc the liver doesn’t work to metabolize drugs

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10
Q

Exclusion by type of headache:

A

-if they have symptoms of migraine -> refer to check if it is a -migraine
-if it is ongoing
-if it is a cluster headache -> behind the eye (bc of severe pain excluded)
-medication overuse -> they have to stop the medication they are taking

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11
Q

What are the 3 types of systemic analgesics?

A

-Salicylates (Aspirin -> acetylsalicylic acid, non acetylsalicylics)
-Acetaminophen
-NSAIDS

-> refer to mild (1-3) and moderate (4-6)

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12
Q

What are the Non-Drug Treatment Approaches

A

Avoid stressors, aerobic, hot or cold compresses on forehead (trick pain pathway)

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13
Q

Which of the 3 analgesics has the longest Onset?

A

Aspirin with 1-2hr
Acetaminophen: 30 min
NSAID (ibuprofen and Naproxen) :15-30 min

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14
Q

What happens when a long-acting drug is given to an older person?

A

The drug will be in the system longer, which makes the dose higher

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15
Q

Why don’t want a long-acting drugs in kids?

A

Bc it takes so much time to get excreted, we don´t a lot of exposure of the drug to the kid -> least amount of drug for the shortest duration in kids and older people bc the kidney and liver decline

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16
Q

Which of the analgesics is eliminated in the Liver?

A

Acetaminophen
NSAIDS (Naproxen and Ibuprofen) and Aspirin (Acetylsalicylic acid) through kidney

17
Q

Why is Aspirin as an irreversibly COX inhibitor concerning?

A

Because it blocks COX for the whole time it is present, meaning that it takes time for the body to excrete the drug before the positive effects of COX-I can be used (f.e. platelet formation)
-> Bleed risk is higher in Aspirin

18
Q

What is special about Acetaminophen (Tylenol)?

A

It is secreted through the liver and it probably doesn’t target inflammation pain, this is why it may not work in every patient

-not for people with low LIVER function
-high dose can damage the LIVER
-but rare side effects: Hepatoxicity (nausea and vomiting), skin reaction, nephrotoxicity, Anemia

19
Q

What is the max dose for Acetaminophen?

A

325-650mg every 4-6 hours, 1000mg ev 6 hr
3000mg a day

pediatrics: 10-15mg/kg/dose ev 4-6hr, 2.6g in 24 hr

20
Q

What are the drug interactions of Acetaminophen (Tylenol)?

A

-Alcohol
-Anticoagulants (Warfarin), chronic use of APAP can increase bleedinmg risk -> anyone that is on a blood thinner is on Tylenol though

21
Q

What are the Salicylates?

A

-Acetylated salicylates, Aspirin, ASA
-non-acetylated salicylates (Magnesium salicylate

22
Q

Why might Aspirin be not the best choice to treat pain?

A

-Irreversible COX-I, II inhibitor and it acts anti-inflammatory only at high doses -> and at high doses, there are side effects: GI ulcer, nausea, vomiting, epigastric discomfort

-it is usually used for cardiovascular protection

23
Q

For which patients is Aspirin avoided?

A

Aspiring allergy, prone to GI bleeding,
!! Renal insufficient patient bc cleared through kidney
children (viral infection) and young adults (< 16y) -> Reyes syndrome (neurological damage, deadly)
Ashtma (may be undiagnosed in kids, deadly), 3rd trimester pregnant (bleed risk when delivering)

24
Q

Drug interaction for Aspirin?

A

-NSAIDs, anticoagulants -> Bleed risk
-Antihypertensive -> ASA may inhibit the effect of beta-blocker, ACE-I, vasodilators, diuretics

-Overdozed patients may experience: Tinnitus

25
Q

What is the max dose for Aspirin?

A

325-650mg every 4-6 hours, 1000mg ev 6 hr
4000mg a day

pediatrics: 10-15mg/kg every 4-6 hours (max of 4000mg/day)

26
Q

What are the NSAIDS?

A

Ibuprofen (Advil, Motrin)
Naproxen (Aleve) longest acting analgesic 12hr

-they have side effects related to GI tract and cardiovascular

27
Q

Drug interaction of NSAID:

A

-With aspirin: Decreased cardioprotective effect of ASA, so separate administration, increased risk of bleed and cardiovascular events

-Antihypertensives: decreased effectiveness

-Anticoagulants: increase of bleeding risk

28
Q

Max dose of NSAID:

A

Ibuprofen:
200-400mg ev 4-6 hr, 1200 mg a day OTC
pediatrics: 5-10 mg/kg/day -> max 4 doses per day 40mg/kg/day

Naproxen:
220mg every 8-12hr (max 660 mg/day)
over age 65 -> 220mg every 12hr (max 440mg/day)
NOT FOR CHILDREN