Musclepain Flashcards

1
Q

What are Common Musculoskeletal Injuries?

A

Strain, Sprains, Tendonitis, Bursitis, Myalgia, Contusions resultant of blunt trauma, muscle soreness

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2
Q

Patient presentation for Acute Injuries?

A

-Diffuse, dull, constant ache or pain
-Onset is acute with injury
-Aggravated or worsened after use -> reduced at rest
-swelling, bruising, erythema, possible joint stiffness
-Duration depends on the severity of the injury

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3
Q

Patient Presentation: Overexertion Injuries:

A

-Diffuse, dull, constant ache or soreness
-Onset is delayed - 8hr after injury

-Weakness/fatigue of muscles
-last for days - peak at 24-48 hr

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4
Q

What are important pain transmitters?

A

Generation of pain:
-Prostaglandin, Bradykinin, inflammatory cytokines
-Neurotransmitter: GABA, substance P, CGRP

TNF alpha, IL production -> pain transmission facilitated
-microglia and astrocytes

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5
Q

What is the Gate control theory?

A

Stimulation of the skin can reduce the overall perception of the actual injury itself

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6
Q

What is RICE therapy?

A

-Rest 1-2 days
-ICE for ASAP for 10-15 min (no longer bc over icing), 3-4x a day for 1-3 days (constrict the vascular to prevent inflammatory agents to come in
-Compression: wrap the injured area
-Elevation -> at or above the level of heart 2-3 hr per day

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7
Q

Explain Heat therapy:

A

-used in non-inflammatory pain, chronic injuries
-48hr after injury -> reduce pain by increasing the blood flow to flush away the p
-do not put it on top of other topical agents or on inflamed areas
don´t use it with a warming agent
-15-20 min, 3-4x a day -> don’t use too long -> overheat

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8
Q

Which analgesics are preferred for non-inflammatory VS inflammatory injuries?

A

Non-inflammatory injuries: Acetaminophen (Tylenol)

Inflammatory injuries: NSAIDs

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9
Q

Which analgesic is the first to prefer for osteoarthritis?

A

Acetaminophen (Tylenol)

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10
Q

When after an injury should analgesics be administered?

A

-Soon after the injury, then taper down the dose and interval as injury improves (1-3 days)
-OTC for 10 days

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11
Q

What are the mechanisms topical products work?

A

-Topical Counterirritant (Gate control theory) -> most of them
-Topical NSAIDs
-Anesthetics
-Topical analgesics

-> they are used in addition to Non-drug treatment and systemic analgesic
-> often combination products

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12
Q

Example of a topical NSAID:

A

Diclofenac
-used for arthritis pain at joints
-applied up on up to two joints, 4x a day / max 7 days

-adverse effects: redness, swelling, skin irritation, used in caution in people with aspirin allergy

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13
Q

How do counterirritants work?

A

-Paradoxal pain relieving effect (Gate control theory) -> less severe stimulus to counter a more intense pain stimulus
-often for older kids and andults
-3-4x a day for 7 day max
-wash hands after using

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14
Q

How do counterirritants work?

A

-Paradoxal pain relieving effect (Gate control theory) -> less severe stimulus to counter a more intense pain stimulus
-often for older kids and adults
-3-4x a day for 7 day max
-wash hands after using
-don’t tightly wrap bc it causes more heat -> more irritating

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15
Q

Example of a Counterirritant: Rubefacient

A

Methyl salicylate
-causes vasodilation and redness -> hot action
-common side effects: skin irritation, systemic absorption possible

-HEAT exposure INCREASES absorption by 3x
-Brand extensions: may have different ingredients with different effects (menthol - cooling AND methyl salicylate-heat)

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16
Q

Example of a Counterirritant: Cooling Agent

A

Menthol
-Anesthetic and counterirritant
-has a cooling effect first (MAIN) -> warm sensation later
-increases absorption of other meds

-Well tolerated, in case of irritation, rash, burning stop using it

17
Q

Example of a Counterirritant: Cooling Agent

A

Camphor
-may cause redness when applied rigorously - rubefacient
-toxic if digested (CNS), tonic-clonic seizures, respiratory depression

18
Q

Topical Counterirritants: causing Vasodilation

A

Histamine dihydrochloride
dilates blood vessels -> impact on prostaglandin biosynthesis to cause vasodilation in an increase of skin temperature

-Side effects: bc of vasodilation it can cause drop in blood pressure when used on huge parts of the body in people with heart condition

19
Q

Topical Counterirritant: Capsaicin

A

-from chili pepper -> HOT
-depletes pain transmitter substance P -> less pain transmission
-> takes time to deplete it -> delayed effect of 14 days -> so not the best for acute injuries, better for chronic injuries

-side effects: burning, stitches, high concentration may cause cough
not for kids bc it is long acting

(CHRONIC injuries are usually not treated with OTC)

20
Q

What are topical anesthetics?

A

-Numbing agent blocks pain transmission

21
Q

Topical anesthetics: Licodaine

A

-Formulations: creams, sprays, patches
-3 to 4h a day - may 8hr
-not for kids younger than 12
-side effects: local irritation, rash, itching - only on clean dry skin and not with other products (accumulative effect)

22
Q

Topical anesthetics: Trolamine Salicylate

A

-targets prostaglandin and inflammation
-insufficient data available about safety and efficacy

-side effects: similar drug interactions and counterindication like aspirin

23
Q

Examples of Natural products/ Homeopathics

A

Hyland´s leg cramps
-target cramping
-they are overseen by Homeopathic pharmacopeia
-safety issue: Cinchona and Viscum
Drug interaction Cinchona -> anitpletletes, anticoagulant, carbamezepine, phenobarbital

Viscum -> has a narrow therapeutic range -> Prgenancy, may stimulate contractions

24
Q

Examples of Natural products/ Homeopathics

A

Hyland´s leg cramps
-target cramping
-they are overseen by Homeopathic pharmacopeia
-safety issue: Cinchona and Viscum
Drug interaction Cinchona -> anitpletletes, anticoagulant, carbamezepine, phenobarbital

Viscum -> has a narrow therapeutic range
-> Prgenancy, may stimulate contractions