pain

Question 1

true or false?

Phenylbutazone provides an increased plane of analgesia for hoof pain/laminitis compared to firocoxib and meloxicam

Answer 1

True

moderate evidence

Question 2

Sedative and antinociceptive effects of different detomidine constant rate infusions, with or without methadone in standing horses

which one was the best?

Answer 2

Methadone with the

highest detomidine dose (DHM)

• 5 µg/kg bwt loading and
• 12.5 µg/kg/h maintenance

may provide sufficient sedation and analgesia for standing surgical procedures and warrants further investigation.

Question 3

is Ascorbic acid and hydrocortison useful in endotoxemia?

Answer 3

Ascorbic acid and HydroCortison appeared to protect against LPS-induced neutrophil depletion

no effect of drug on clinical signs or pro-inflammatory cytokine gene expression or production (like SAA)

Question 4

Prediciting survival in horses with pleuropneumonia

Answer 4

Increased serum creatinine concentration at presentation was negatively associated with survival

Question 5

Insulin dysregulation in SIRS horses

Answer 5

• survivors : higher serum insulin and lower serum glucose concentration on admission.
• survivors: hyperinsulinemia at any time during hospitalization were 4 times more likely to survive whereas
• NS: hyperglycemic at any time during hospitalization 5 times less likely to survive.
• Serum glucose concentration and presence of hyperglycemia both were associated with severity of disease.
• Insulin/glucose ratio, reflecting insulin secretion, was significantly higher in survivors whereas
• glucose/insulin ratio was significantly lower in nonsurvivors: peripheral tissue insulin resistance

Question 6

Definition of SIRS

Answer 6

presence of 2 of the following criteria:

• hyperthermia (>38.7C) or hypothermia (<36)
• tachycardia(45 beats/min),
• tachypnea (>24 breaths/min),
• leukopenia or lycocytosis(WBC <6000/lL or > 12)
• > 10% band neutrophils.

whereas i think that one of the following: fever or blood abnorm, HAVE TO BE present)

Question 7

Mechanism of action of paracetamol

Answer 7

Most evidence suggests it acts on serotonergic and cannabinoid pain pathways in the CNS and has only very mild interactions with cyclooxygenase (COX);

oral bioavailability excellent

laminitis

Question 8

problem with gabapentin

Answer 8

poor bioavailability in horses and probably always fails to reach plasma levels necessary for analgesia