Pain

Question 1

Pain definition

Answer 1

Unpleasant sensory and emotional experience associated with actual or potential tissue damage

Question 2

Acute pain

Answer 2

Identified reason
Sudden pain
Last for days - weeks

Question 3

Chronic pain

Answer 3

No identified reason

Lasts for three months or more

Question 4

Breakthrough pain

Answer 4

Sudden flare or pain that breaks through medication prescribed to control chronic pain. It is a transitory exacerbation of pain with relatively stable and controlled baseline pain.

Question 5

Timing of break through pain

Answer 5

Peak intensity at 3-5 minutes

Lasts for 30 minutes

Question 6

Transdermal patch timings

Answer 6

Therapeutic effect reached at 12-16 hours

Steady state blood level reached at 48 hours

Question 7

Layers of transdermal patch

Answer 7

• Polyester/ethylene backing
• Drug reservoir
• Polymer rate controlling membrane
• Silicone adhesive layer

Question 8

Directions of actiq-mucosal fentanyl

Answer 8

1. Place inside cheek
2. Move up and down constantly
3. Change to other cheek at intervals
4. Aim to consume in 15 minutes

Question 9

Actiq-mucosal timings

Answer 9

Onset of action at 5-15 minutes
Peak intensity at 20-40 minutes
50% bioavailibility

Question 10

Buccal fentanyl

Answer 10

Dissolves with effervescent reaction.
Transient shift in pH enhances rate and extent of absorption.
68% bioavailibility