PAH/PE/Thromboembolism

Question 1

What are the 4 types of drugs used to treat pulm hypertension

Answer 1

1. Prestanoids
2. Endothelin antagonists
3. PDE 5 inhibitors
4. Guanylate Cyclase Sensitizers

Question 2

What drugs are prostanoids?

Answer 2

1. Epoprostenol
2. Treprostinil
3. Iloprost
4. Selexipag

Question 3

What drugs are endothelin Antagonists?

Answer 3

1. Bosentan
2. Ambrisentan
3. Macitentan

Question 4

What drugs are PDE 5 inhibitors

Answer 4

1. Sildenaphil
2. Tadalafil

Question 5

Guanylate Cyclades Sensitizer drug

Answer 5

Riociguat

Question 6

What are prostanoids used for and what is the MOA (3)

Answer 6

To improve exersice capacity in PAH.
Direct vasodilation, inhibits platelet aggregation and suppresses smooth muscle growth

Question 7

What is the risk of giving treprostinil through IV?

Answer 7

Risk of infection and sepsis

Question 8

Common side effects of prostanoids

Answer 8

Extreme reduction in BP
Increased risk of bleeding

Question 9

What is unique about treprostinil and Selexipag drug interactions.

Answer 9

Dose must be modified when given w CYP2C8 inhibitors or activators

Question 10

Which prostanoid causes hypertension and syncope

Answer 10

Iloprost

Question 11

What is the MOA of endothelin antagonists

Answer 11

Blocks ETa and ETb endothelin receptors

Question 12

What organ should be checked while on Bosentan

Answer 12

Liver (has hapato and embryo toxicity)

Question 13

What should women on birth control concidering when taking bosetan?

Answer 13

It decreases contraception effectiveness

Question 14

What are the common adverse reactions of Bosentan

Answer 14

RTI, pyrexia, URTI and anemia

Question 15

What drug can be administered with Tadalafil to lower PAH progression? And is selective ETa!!!

Answer 15

Ambrisentan

Question 16

What tests and follow up should be performed while on Ambrisentan

Answer 16

Bc of teratogen effect, check for pregnancy during usage every month

Question 17

What drug can cause pulmonary edema and fluid retention?

Answer 17

Ambrisentan

Question 18

What drug should not be used with nitrates or a history of hypersensitivity

Answer 18

Sildenafil

Question 19

What drug is similar with a longer 1/2 life than sildenafil?

Answer 19

Tadalafil

Question 20

What drugs should not be used with sildenfil

Answer 20

Viagra or other PDE 5 inhibitors

Question 21

What additional indication does Riociguat have?

Answer 21

Chronic thromboembolic PH
Do not use in pregnancy or ILD

Question 22

What drug needs to be separated from antacids by 1 hour?

Answer 22

Riociguat