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Pulm PHARM > Asthma And COPD > Flashcards

Asthma And COPD Flashcards

1
Q

What is the major route of inhaled drugs?

A

80% is swallowed, but the inhaled portion still does most the work

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2
Q

What is the drug treatment plan for asthma? For COPD?

A
  1. ICS - LABA - LAMA
  2. LAMA - LABA - ICS
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3
Q

What are the common B2 agonists (5)

A

Albuterol, terbutaline, metaprotetenol, pirbuterol, levalbuterol

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4
Q

What is the only b2 drug avaliable for sub q injection

A

Terbutaline

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5
Q

Which B 2 agonist is used for bronchial asthma and reversible bronchospasm

A

Metaproterenol

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6
Q

What is the major risk factor for metaproterenol

A

Production of paradoxical bronchospasm

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7
Q

Which B2 agonist produces significant cardiovascular effects in patients

A

Pirbuterol

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8
Q

Which drug can be used in patients as young as 4 with asthma’s

A

Levabuterol. Prevents bronchospasm

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9
Q

Name the inhaled corticosteroids (7)

A

Beclomethasone, budesonide, ciclesonide, fluticasone, mometasone, triamcinolone, prednisone

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10
Q

What is a risk when comming off of systemically active corticosteroids in favor of inhaled ones

A

Adrenal insufficiency. Particularly with beclomethasone.

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11
Q

What cell line is reduced with ICS

A

Eosinophils, t lymphocytes and mast cells

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12
Q

What ICS drug can only be used as maintenance

A

Budesonide

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13
Q

In which patients is budesonide and mometasone contraindicated in

A

People w milk sensitivity

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14
Q

Which drug should not be given during canida infection but reduces its risk

A

Ciclesonide

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15
Q

Which ICS (2) can reduce the need for oral corticosteroids

A

Flunisolide and Triamcinole

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16
Q

What warning is given with fluticasone

A

Candida infection can occur during this ICS, rinse mouth after inhalation

17
Q

Which CS can be used to treat certain endocrine conditions and severe asthma flair ups

A

Prednisone

18
Q

What is the warning associated with prednisone

A

May cause pituitary adrenal axis supression

19
Q

Name the LABA (5)

A

Fomoterol, Salmeterol, indacaterol and vinanterol, oloaterol

20
Q

Why are LABAs only used last in asthma

A

Causes asthma related death and hospitalizations. Mostly used for COPD

21
Q

What is the main use of Olodaterol

A

Long term daily maintenance treatment for airway obstruction. Always use with ICS

22
Q

Name the anticholenergic drugs used in asthma and COPD

A

Atropine, ipratropium, Tiotropium, Aclinium

23
Q

What should the dose of atropine be restricted to in recurrent use

A

2-3 mg

24
Q

Which drug is relatively free if systemic atropine effects

A

Ipratropium

25
Q

How do methylxanthines work?

A

Smooth muscle relaxation and suppression of airway response to stimuli

26
Q

Name the Leukotriene R antagonist/Lipoxygenase Inhibitor (2)

A

Zafirlukast and montelukast

27
Q

What are the main effects of zafirlukast and montelukast

A

Anti inflammatory and glucocorticoid sparing

28
Q

What is the purpose of leukotryine antagonists

A

Treat and prevent acute asthma attacks by blocking cysteinyl leukotriene receptors

29
Q

What is the MOA of montelukast

A

Inhibits LTD4 at the CysLT1 receptor without agonist activity

30
Q

What is the warnings associated with zileutron

A

Immediate release withdrawn from market. Controlled release is not recommended in active liver disease. Used for chronic asthma
Leukotryine antagonist

31
Q

What is the monoclonal antibody for asthma

A

Omizumab

32
Q

What is omalizumab indicated to treat

A

Severe persistent asthma, chronic idiopathic urticaria (antibody)

33
Q

What are the warnings of Omalizumab

A

Can cause anaphylaxis, (life threatening) monitor closely directly after administration

34
Q

What do you treat asthma patients with symptoms of COPD with

A

Triple therapy (ICS, LABA, LAMA)

Pulm PHARM (4 decks)

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