Paget's disease of bone

Question 1

What is Paget’s disease of bone?

Answer 1

Excessive/uncontrolled bone turnover as a result of excessive osteoclast and osteoblast activity

Question 2

Which group of patients does Paget’s disease typically affect?

Answer 2

Older adults

Question 3

Describe the clinical features of Paget’s disease

Answer 3

Bony pain, typically affecting:

• Skull
• Spine
• Pelvis
• Femur

Question 4

What is the typical pattern on blood tests in Paget’s disease of bone?

Answer 4

Isolated rise in ALP

Question 5

Describe the medical management of Paget’s disease

Answer 5

Bisphosphonates

Question 6

Give two examples of complications of Paget’s disease

Answer 6

• Osteosarcoma

- Spinal stenosis (spinal cord compression)