Pages 41-52 Flashcards
Labs in DKA?
Plasma glucose: over 250 Arterial pH: under 7.30 Serum bicarb: under 18 Urine ketones: +++ Serum ketones: +++ Serum osmolality: increased Anion gap: over 12
Labs in HHS?
Plasma glucose (mg/dL): over 600 Arterial pH: over 7.30 Serum bicarbonate: over 18 Urine ketones: negative Serum ketones: negative Serum osmolality: greatly increased Anion gap: Normal (12-16)
Average fluid loss in KDA and HHS?
DKA: 3-6 liters
HHS: 8-10 liters
How to correct fluids in DKA and HHS?
- Start with isotonic saline 15-20 ml/kg per hour
- Switch to one-half isotonic saline serum Na
- Add dextrose to IVF when serum glucose reaches 250
How to administer insulin in DKA and HHS?
- Only after adequate fluid resuscitation
- Start with an infusion of regular insulin at 0.1 U/kg/hr.
- Double dose if glucose doesn’t fall by 50-70 mg/dL in first hour
How to correct K in HHS and DKA?
- If the K under 3.3, DELAY insulin therapy until fluid and potassium replacement
- Administer K w/ initial IVF if K is normal or low and maintain between 4 - 5 mEq/L
When is bicarb administration needed in DKA and HHS?
- Severe acidosis with pH < 6.90
- Severe life-threatening hyperkalemia
- Seizures
- Cardiac or persistently hypotensive patient
Monitoring of labs in HHS and DKA?
- Glucose every hr. until stable, then every 2 - 4
2. BMP and blood pH every 2 - 4 hours until patient stabilizes
What can HYPOglycemia mimic?
- Coma
- Stroke
- Seizures
- Syncope
Oral administration of glucose in hypoglycemia?
300g (1200cal) of carbohydrate should be given:
- Soda, juice, sandwich, snacks
- Complex carbohydrates better at maintaining levels
IV administration of glucose in hypoglycemia?
Adults: 50 ml of 50% Dextrose in Water (D50)
Peds: 1 ml/kg of 25% Dextrose in water
What needs to be given to alcoholics with glucose?
Thiamine to prevent Wernicke’s Encephalopathy
Use of glucagon in hypoglycemia?
Can be used when no IV access
- Adults: administer 1 mg IM
- Kids: 0.5 mg if under 20 kg
Use of octreotide in hypoglycemia?
May be useful in the setting of sulfonylurea-induced hypoglycemia not responsive to other therapies
Triad thyroid storm?
- High fever (sometimes as high as 106)
- Exaggerated tachycardia
- CNS dysfunction
Also - Tremulousness
- Agitation
- Psychosis
- N/V
Diagnosis thyroid storm?
- Elevated T3/T4
- Elevated T3 uptake
- LOW TSH
How does PTU work?
Blocks synthesis of thyroid hormone
- Preferred over methimazole because PTU also reduces peripheral conversion of T4 to T3
How do you block release of thyroid hormone?
- Inorganic iodine at least 1 hour after antithyroid meds
- Lugol’s solution
- Can use lithium if allergic to iodine
How do you stop effects of thyroid hormone?
Propranolol - antagonizes the hyperadrenergic effects of thyroid hormone
How to treat hyperthermia in thyroid storm?
Acetaminophen
Definition hyperkalemia?
Serum potassium of greater than 5.5 mEq/L
Effect of hyperkalemia on the heart?
2nd and 3rd degree heart block, wide complex tachy, and progression to v-fib and asystole
Diseases leading to hyper K?
- CKD
- DKA
- Rhabdo