Pages 21-30 Flashcards
Csf Findings in Bacterial meningitis?
Opening Pressure: Elevated White Blood Cell count: 1,000-10,000* Neutrophils: >80% Glucose: Reduced Protein: Elevated Gram Stain: Bacteria
Csf Findings in Viral meningitis?
Opening Pressure: Normal White Blood Cell count: Less than 300 Neutrophils: 1- 50% Glucose: Normal Protein: Normal Gram Stain: Nothing
Csf Findings in fungal meningitis?
Opening Pressure: Elevated White Blood Cell count: Less than 500 Neutrophils: 1- 50% Glucose: Normal Protein: Elevated Gram Stain: Nothing
Treatment order in meningitis patients needing CT?
Prior to CT:
- Blood cultures should be drawn
- Steroids
- Empiric antimicrobial therapy
Rx encephalitis?
Supportive Care
*HSV encephalitis: ACYCLOVIR
IV emperic meningitis rx based on age?
- Less than 1 month: Ampicillin + Cefotaxime or Gent
- 1-3 months: Ampicillin and Cefotaxime
- Children over 3 months: Dexamethasone b4 Cephalosporin + Vancomycin
- 50 years or younger: Dexamethasone b4 Cephalosporin + Vancomycin
- Over 50: Dexamethasone b4 Cephalosporin + Vancomycin AND Ampicillin
Presentation subarachnoid hemorrhage?
- Acute onset thunderclap HA
- Typically occipital or unilateral
- Significant portion also have a warning (sentinel) HA - LOC
- Vomiting
- Neck stiffness
- Seizure
RF SAH?
- FH = 3- 5 x Risk
1. Recent exertion
2. Hypertension
3. Excessive alcohol consumption
4. Sympathomimetic use
5. Cigarette smoking
Diagnosis SAH?
- CT: 7% not visualized on initial head CT
- LP:
- Absence or clearing of blood.
- Xanthochromia
How to analyze blood in LP of SAH?
- Normal CSF does not contain RBCs
- Many sources state that if # RBC decreases by 50% from tube 1 to tube 4, blood attributed to tap trauma
- However, this decrease can occur in SAH as well
- Tap should only be labeled ‘traumatic’ if 4th tube is fewer than 5 RBCs per HPF
What is xanthochromia?
Yellow or pink discoloration of supernatant once the CSF is centrifuged
- Results from breakdown of RBC
- Determined by visual inspection or spectrophotometry
- Presence of xanthochromia highly sensitive of SAH
Next step if CT or LP consistent with SAH?
Angiography is necessary
- Conventional digital subtraction angiography (DSA) is gold standard
Mgmnt SAH?
- Assess and reassess ABCD’s
- Discontinue or reverse anticoagulation
- Prevent hypotension and hypoxemia
- Control ICP
- Seizure prophylaxis
- Treat fever and infection aggressively
- Control blood glucose: target 140-185
How do you control ICP?
- Monitor/lower BP in consult w/ neurosurg
- Elevate head of the bead to 30 degrees
- Provide sedation and analgesia
- If signs of rapidly rising ICP or herniation: mannitol or mild hyperventilation: target CO2 ~ 30 mmHg
When are epileptic patients prone to seize?
- Medical noncompliance: most common cause
- Sleep deprivation
- Emotional or physical stress
Causes of secondary seizure?
- Hypoglycemia: most common cause
- Hyponatremia
- Alcohol withdrawal, drugs, toxins
- Trauma
- Tumor
- Infection
- Eclampsia
Diagnosis mimicking seizure?
- PNES
2. Syncope
Lab tests in seizure patient?
First time: 1. HcG 2. CMP 3. Head CT 4. MRI / EEG - outpatient Recurrent: (above plus) 1. Phenytoin 2. Carbamazepine 3. Phenobarbital 4. CT head only if seizure quality is different or in status epilepticus 5. Continuous EEG if status
Vitals in alcohol withdrawal?
- Tachycardia
- Hypertension
- Hyperthermia
- Tachypnea
Drugs causing seizures?
- Isoniazid: TB patients
- TCAs - widened QRS
- Prominent terminal R in AVR
Characteristics of PNES?
- Rhythmic, controlled shaking activity
- Ability to talk or follow commands during the seizure
- Recall of a seizure that involves both sides of the body
- Lack of a postictal period
What is status epilepticus?
Single unremitting seizure w/ duration longer than 5-10 min or frequent clinical seizures w/o interictal return to baseline
Rx Status epilepticus?
- First line: Benzos (usually lorazepam)
- Second: fosphenytoin/phenobarbital/VPA
- Third: versed/pentobarbital/propofol infusions