Paeds peer teaching part 2 Flashcards
Cystic fibrosis treatment
Chest physio High calorie diet CREON tablets for pancreatic enzymes Prophylactin flucox and vaccinations Nebulised dornase alfa Nebulised hypertonic saline Fertility treatment Genetic counselling
If you have two parents who are CF carriers, whats your chance of getting it
25%
What causes breathlessness in anaphylaxis
Angio oedema
Whats the best investigation for cystic fibrosis
Sweat test
Right illiac fossa tenderness
IBD
What type of anaemia do you get from GI blood loss
Microcytic
What happens to albumin in diarrhoea
Low because lost in stool and poorly absorbed because of malabsorption
Best investigation for inflammatory bowel disease
Colonoscopy
Features of both UC and crohns
Diarrhoea Abdo pain Weight loss N and V Faltering growth Delayed puberty Reduced appetite Malaise/ fatigue Fever
Features of IBD unique to crohns
Termina ileum disease (RLQ pain)
Perianal tags, fistulae, abscesses
Gallstones
Features of IBD unique to UC
Left lower quadrant tenderness
Bloody diarrhoea
Macroscopic and microscopic crohns features
Skin lesions, cobblestone mucosa
non caseating granulomata, transmural inflammation
Which IBD do you get toxic megacolon in
UC
Macroscopic and microscopic UC features
Continous, mucosal ulceration. No granulomas. Submucosal inflammation
Crohns induction of remission treatment
Enteral nutrition (modulen) then glucocorticoids
Crohns maintenance of remission treatment
Azathioprine
UC induction of remission treatment
Mesalazine or glucocorticoids
Treatment of toxic megacolon
IV, fluids, glucocorticoids, surgery
Maintenance of remission in UC
Mesalazine
Define coeliac
Autoimmune condition caused by an inflammatory response by the GALT to gliadin (HLA-DR3-DQ2)
Which antibodies are present in coeliac
Tissue transglutaminase
Endomysial cell antibodies
Diagnosis of coeliac
Dont eat gluten for 6 weeks then test for antibodies then endoscopy and biopsy
Microscopic changes in coeliac
Long crypts, lymphocyte infiltration, flattened villi
Magement of coeliac
Gluten free diet
Symptoms of coeliac
Unintended weight loss Fatigue Chronic diarrhoea Flatulence Severe recurrent abdo pain Pale stools
Causes of gastroenteritis
Virus ! (rotavirus, adenovirus, enterovirus)
Bacterial- campylobacter jejuni, E. coli, shigella, salmonella
Clinical features of gastroenteritis
Acute onset diarrhoea and vomitting Fever Lethargy Abdominal pain Poor feeding
If watery diarrhoea returns after gastroenteritis whats going on
Post gastroenteritis syndrome (may have developed lactose intolerance)
When should you take stool samples in gastroenteritis
Not sure of diagnosis Septic Bloody More than 2 weeks Immunocompromised
Management of gastroenteritis
Oral rehydration solution
Breast feed
NG fluids
Hospitalisation if needed
Common symptoms of appendicitis
RLQ pain, worse on movement, Vomiting, fever, peritonism
Diagnosis of appendicitis
Clinical diagnosis
Ultrasound
Treatment of appendicitis
Appendicectomy
Common symptoms of intussusception
Sudden colicky pain, drawing up legs, pale, vomiting, redcurrent jelly stools
Diagnosis of intussusception
Target sign on ultrasound
Management of intussusception
IV fluids and antibiotics
Pneumotic reduction air enema
Laparotomy
Common symptoms of mesenteric adenitis
Mimics appendicitis, pharyngitis, cervical lymphadenopathy
Treatment of mesenteric adenitis
Analgesia
Hydration
Common symptoms of inguinal hernia
Reducible lump in groin, if strangulated= nausea, vomiting, off food, sever pain
Investigation of inguinal hernia
Clinical exam- rule out testicular torsion
Treatment of inguinal hernia
Early surgical intervention
Symptoms of irritable bowel syndrome
Pain relieved on defecation, bloating, mucus in stool, lethargy
Treatment of irritable bowel
Small regular meals, eliminate triggering foods
Symptoms of abdominal migraine
Pain lasting 2-72 hours, nausea, vomiting, anorexia, pallor
Treatment for abdominal migraine
Analgesia, avoid triggers, prophylaxis
What type of bilirubinaemia causes jaundice in the first 24 hours
Unconjugated
Causes of jaundice in first 24 hours
Haemolytic disease of the newborn Hereditary spherocytosis G-6-PD deficiency Sepsis TORCH infections Crigler-najjar syndrome
Causes of jaundice after 2 weeks
Biliary atresia
Hypothyroidism
UTI
Gilbert syndrome
Jaundice investigations
Bilirubin chart FBC Blood film Unconjugated and conjugated Blood typing of mother and baby Direct Coombs test
What does the direct coombs test look for
Haemolysis
How does the molecule go from haem to conjugated bilirubin
Haem
Biliverdin
Unconjugated Bilirubin
Conjugated bilirubin
What is biliary atresia
Narrowing blockage or absence of part of the biliary tree. Leads to a conjugated bilirubinaemia
Presentation of biliary atresia
severe jaundice at day 2 (high conjugated), pale white stools
Biliary atresia treatmtent
Ultrasound of gall bladder and bile ducts
TBIDA radioisotope scan
Kasal surgery
Anti D injections
Given at 28 weeks and again at birth or after a sensitisation event
Kliehauer test
Assess how much fetal blood mixed with the mothers blood
Hereditary spherocytosis presentation
Newborn with jaundice and splenomegaly
Describe hereditary spherocytosis pathology
Autosomal dominant. Sphere shaped red blood cell.
Aplastic crisis if also parvovirus
Investigations of spherocytosis
FBC, Blood film, Coombs test
Treatment of spherocytosis
Splenectomy
Cholecystectomy
Folate
Penicillin for life
G6PD deficiency pathology
Baby picks up infection and turns yellow. X linked recessive.
G6PD triggers and presentation
Infection, medication or broad beans causes splenomegaly and gall stones
Investigations of G6PD deficiency
Heinz bodies on blood film
G6PD enzyme assay
G6PD fun fact
Caused by fava beans and Heinz bodies is a sign of it