Paeds GI and Liver Flashcards

1
Q

What is pyloric stenosis?

A

Thickening and narrowing of the pylorus

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2
Q

When does pyloric stenosis present?

A

First 2-8 weeks of life

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3
Q

What is the vomit like in pyloric stenosis?

A

Projectile vomit

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4
Q

Why is there projectile vomiting in pyloric stenosis?

A

Increasing peristaltic waves in the stomach
Food cannot pass to duodenum due to hypertrophy
Results in projectile vomiting.

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5
Q

Findings on examination in pyloric stenosis?

A

Firm round mass in upper abdomen

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6
Q

What do blood gas results show in pyloric stenosis?

A

Hypochloric metabolic alkalosis

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7
Q

Which investigation diagnoses pyloric stenosis?

A

Abdo USS

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8
Q

What is the management of pyloric stenosis?

A

Laparoscopic pylorotomy (incision in the smooth muscle of the pylorus to widen the canal)

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9
Q

What is infant colic?

A

Baby draws up their knees and is accompanied by inconsolable crying before passing wind

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10
Q

What are the clinical features of CMPA?

A

Symptoms 2 hours post feed
Pruritus
Erythema
Angioedema around lips
Nausea
Vomiting
Diarrhoea
Colicky pain

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11
Q

How is CMPA diagnosed?

A

Diagnosed clinically

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12
Q

Management of CMPA?

A

Hydrolysed formula milk
Soya milk (over 6months)

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13
Q

What is intussuception?

A

Invagination of one part of the bowel into another

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14
Q

What are the consequences of intusseption?

A

Bowel obstruction

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15
Q

When does intussuception commonly occur?

A

Ages 3months to 2 years

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16
Q

What are the clinical features of intussusception?

A

Paroxysmal colicky pain
Sudden onset of inconsolable crying episodes
Red current jelly stools

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17
Q

What are the stools like in intussuception?

A

Red current jelly stools

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18
Q

What can be felt on examination in intussuception?

A

Sausage shaped abdo mass in the right upper quadrant

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19
Q

Which part of the bowel does intussuception most commonly occur?

A

Ileocaecal valve

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20
Q

What is the preferred method of diagnosis for intussuception?

A

USS

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21
Q

What signs can be seen on transverse plane with USS in intussuception?

A

Doughnut sign

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22
Q

What is the management of intussuception?

A

Fluids
NG tube
Air or contrast enema to reduce intussuscepted bowel
Surgical reduction

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23
Q

What is Meckel’s diverticulum?

A

Remnant from the growing foetus of stomach or pancreas tissue, usually asymptomatic but can begin to secrete acid and form ulcers in the small intestine

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24
Q

Symptoms of meckel’s diverticulum?

A

Blood in the stoolS
Abdo pain

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25
Q

What are the risk factors for acute apendicitis?

A

Genetics
Caucasian
More common in summer

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26
Q

What is the pathophysiology of appendicitis?

A

Direct luminal obstruction of the appendix
Faecolith or impacted stool
Bacteria accumulate cause acute inflammation
Reduced venous drainage, and inflammation causing increased pressure and ischaemia of the appendix

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27
Q

Symptoms of appendicitis?

A

Anorexia
Vomitting
Abdo pain initially centrally then localising to the right hand side

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28
Q

Signs of appendicitis?

A

Rebound tenderness at mc burnleys point
Rosving’s sign (RIF pain on palpation of the LIF)
Guarding

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29
Q

Which score is used for appendicitis?

A

RIFT

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30
Q

What investigations should be carried out in cases of suspected appendicitis?

A

Urinalysis (rule out UTI)
Pregnancy test to rule out ectopic
USS or CT if clinical features are inconclusive

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31
Q

What is Hirschsprung disease?

A

Impaired nerve supply to the distal portion of the colon
This impacts peristalsis and can cause bowel obstruction.

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32
Q

What are the clinical features of hirschprungs?

A

Severe constipation
Not passing meconium within 24 hours
Abdo distention
Bile stained vomit

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33
Q

What is the gold standard investigation for hirschprungs?

A

Rectal suction with biopsy of the submucosa

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34
Q

What is the management of Hirschprungs?

A

Resection of the bowel with impaired nerve supply

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35
Q

What are the most common causes of gastroenteritis?

A

Rotavirus
Campylobacter
Norovirus
Adenovirus
E.coli

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36
Q

Clinical features of gastroenteritis?

A

Loose/watery stool
Vomiting
Abdocramps/pain
Mild fever

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37
Q

Management of gastroenteritis?

A

Assess how dehydrated the child is, in order to determine fluids

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38
Q

What must you not give in cases of gastroenteritis with diarrhoea?

A

Antidiarrhoeal agents as this prevents the excretion of the causative organisms.

39
Q

What symptoms of gastroenteritis suggest an alternative diagnosis?

A

Temp above 38C
Breathlessness or tachypnoea
Altered GCS
Blood/mucus in the stool

40
Q

How do you assess weight loss in children whom you do not have a previous weight?

A

Calculate how much they should weigh based off age, and work out difference between that and current weight.
(age +4) x2

41
Q

Which fluids should be given in neonates?

A

10% glucose

42
Q

What are the rules for maintenance fluid prescribing in paediatrics for a 24 hour period?

A

100ml/kg for first 10kg
50ml/kg for 10-20kg
20ml/kg for over 20kg
Divide by 24 if you want per hour

43
Q

What is the max amount of fluids that can be prescribed for girls?

A

2L

44
Q

What is the max amount of fluids that can be prescribed for boys?

A

2.5L

45
Q

What is the first line type of fluids for children?

A

0.9% saline plus 5% glucose

46
Q

What are the features of 5% dehydration?

A

Reduced urine output
Well ish but some signs
Unsettled
Normal skin
Slightly sunken eyes
Reduced tears
Dry mouth

47
Q

What are the features of 10% dehydration?

A

Lethargic and confused
Unwellm
Weak peripheral pulses
Prolonged cap refil
Cold extremities
Pale and mottled
Hypotension is late sign

48
Q

How do you calculate the fluid deficit?

A

% dehydration x Weight (kg) x10

49
Q

What is a fluid challenge?

A

5ml every 5 mins of squash to see if they can keep it down

50
Q

Which part of the bowel does crohns affect?

A

Mouth to anus

51
Q

What is the characteristic appearance of crohn’s?

A

Transmural inflammation
Discontinuous with skip lesions
Non-caseating granulomatous inflammation
Deep ulcers and fissures

52
Q

What are the characteristic symptoms of crohns?

A

Abdo pain
Diarrhoea
Weight loss
Oral lesions
Uveitis
Erythema nodosum

53
Q

What are the extra intestinal features of crohns?

A

Erythema nodosum
Oral lesions
Perianal skin tags
Uveitis
Arthralgia

54
Q

What investigations would you do for crohns?

A

Faecal calprotectin
Stool sample (rule out infectious cause)
Colonoscopy

55
Q

Which drugs are used to maintain remission in crohns?

A

Azathioprine

56
Q

What kind of diet should be encouraged to maintain remission in crohns?

A

Polymeric diet (liquid diet/entral diet)

57
Q

Which part of the bowel does UC affect?

A

Colon

58
Q

What are the findings in UC on histology?

A

Continuous ulcers
Mucosal inflammation
Crypt damage

59
Q

How to treat mild UC?

A

Mesalazine

60
Q

What are the symptoms of UC?

A

Rectal bleeding
Diarrhowa
Colicky pain
Erythema nodosum
Arthritis

61
Q

What can be prescribed in children with constipation?

A

Movicol

62
Q

What is kwashiorkor?

A

Deficiency of protein in the diet

63
Q

What is marasmus?

A

Deficiency of all nutrients from the diet

64
Q

Characteristic symptoms of kwashiorkor?

A

Stomach oedema
Inability to gain weight or grow
Oedema of hands and feet

65
Q

What is the treatment of marasmus and kwashiorkor?

A

Slowly increasing calorie intake through several small meals.
Multivitamins
Protein supplements

66
Q

What is coeliac disease?

A

Immunological respinse to gliadin

67
Q

What are autoantibodies developed against in coeliac disease?

A

Tissue transglutaminase

68
Q

What is the gold standard test for coeliac disease?

A

Duodenal biopsy

69
Q

Common symptoms of coeliac disease?

A

Loose stools
Steatorrhea
Failure to thrive and weight loss

70
Q

What is the cause of jaundice?

A

High levels of unconjugated bilirubin in the blood causing yellowing of the skin

71
Q

When is jaundice considered normal?

A

2-14 days old

72
Q

When is jaundice abnormal?

A

< 24 hours old jaunduce is always abnormal

73
Q

When should you be concerned about the length of time jaundice is lasting?

A

Lasts longer than 2 weeks this can be pathological

74
Q

What is the usual cause of jaundice less than 24 hours old?

A

Haemolysis

75
Q

What is rhesus haemolytic disease?

A

Mum us Rh -ve and baby is +ve
Blood mixing during delivery can cause haemolysis, leading to jaundice

76
Q

How is rhesus haemolytic disease prevented?

A

Anti D at 28 weeks and after delivery

77
Q

What is ABO incompatibility?

A

WHen mum is O and baby is either A or B.
Mum can develop anti A or Anti B just by immune respinse to common pathogens
These can pass across the placenta causing haemolysis in baby

78
Q

Which test is used to diagnose ABO incompatibility?

A

Coombes test

79
Q

What are the TORCH infections?

A

Toxoplasmosis
Syphilis
Parovirus
Varicella zoster
Rubella
CMV
Herpes/hepatitis

80
Q

Other causes of jaundice in babies under 24 hours old?

A

TORCH
ABO incompatibility
G6PD deficiency
Hereditary spherocytosis

81
Q

What are the causes of jaundice between 2-14 days old?

A

Physiological jaundice due to liver not working as fast
Breast milk jaundice (feeding difficulties leading to dehydration and impaired bilirubin elimination)

82
Q

What are the causes of jaundice lasting longer than 2 weeks?

A

Breast milk jaundice
Congenital hypothyroidism
CF
Biliary atresia

82
Q

What are the causes of jaundice lasting longer than 2 weeks?

A

Breast milk jaundice
Congenital hypothyroidism
CF
Biliary atresia

83
Q

What is kernicterus?

A

Acute bilirubin encephalopathy

84
Q

What is the pathophysiology of kernicterus?

A

Deposition of bilirubin in the basal ganglia and brainstem

85
Q

Symptoms of kernicterus?

A

Seizures
Hypertonia
Opisthotonus (dramatic abnormal posture causing arched back)

86
Q

What is the treatment for jaundice?

A

Phototherapy is first line

87
Q

What is biliary atresia?

A

Obstruction or absence of the lumen in the bile duct. So CBD may be missing or even the gall bladder itself

88
Q

What is the pathophysiology of biliary atresia?

A

Bile duct is blocked, leading to build up of bile back to the liver
Increase pressure in the liver
Causes unconjugated bilirubin to leak into the blood

89
Q

Treatment for biliary atresia?

A

Kasai procedure (surgical treatment)
Liver transplant

90
Q

What is a choledochal cyst?

A

Congenital abnormality of the bile duct causing a swelling. Bile backs up into the liver

91
Q

Symptoms of choledochal cyst?

A

Abdo mass
Pain in RUQ
Jaundice
N&V
Fever

92
Q

What signs are seen on USS in intussuception?

A

Target sign

93
Q

After starting phototherapy how often should serum bilirubin be checked?

A

Every 4-6 hours
Can be lowere to 12 hours when bilirubin is stable