Paeds- Endo and Reproductive Flashcards
give the fasting, OGTT and HbA1c levels for:
diabetes
fasting- >7mmol/L
OGTT- >11.1mmol/L
HbA1c- >6.5%
give the fasting, OGTT and HbA1c levels for:
normal levels
fasting- 3.5-5.6mmol/L
OGTT- <7.8mmol/L
HbA1c- 4-5.6%
give the fasting, OGTT and HbA1c levels for:
impaired glucose tolerance/ pre-diabetes
fasting- <7mmol/L
OGTT- 7< x <11 mmol/L
HbA1c- 5.7-6.4%
symptoms of DKA
- vomiting
- acidosis
- reduced conscious level
- ketonuria
- Kussmaul breathing
- ketonic breath
how is DKA managed?
- resuscitate
- correct dehydration
- insulin after 1 hour- wait 1 hour to reduce hypokalaemia risk
- monitor
aetiology of hypoglycaemia
- excess exogenous insulin (e.g. too much insulin in a diabetic patient)
- B-cell tumour
- non-insulin causes- liver disease, ketonic hypoglycaemia, addisons
how is severe hypoglycaemia managed?
- nil by mouth
- glucagon SC or IM injection
- glucose IV
- give sugar when conscious
congenital causes of hypothyroidism
- maldescent of thyroid
- dyshormonogenesis
- iodine deficiency
- TSH deficiency- pituitary dysfunction
acquired causes of hypothyroidism
prematurity
Hashimotos
Downs
how does a paediatric patient present with congenital hypothyroidism?
- difficult- features become more obvious with age
- faltering growth
- prolonged jaundice
- constipation
- large tongue
- goitre
- umbilical hernia
- delayed development
how does a paediatric patient present with acquired hypothyroidism?
- short stature
- cold intolerance
- dry skin
- bradycardia
- thin, dry hair
- delayed puberty
- obesity
how is hypothyroidism managed?
levothyroxine
what is a major complication of hypothyroidism and how is it managed?
thyroid storm !
IV hydrocortisone, IV fluids and propanolol
what is congenital adrenal hyperplasia?
most common non-iatrogenic cause of insufficient cortisol and mineralocorticoid secretion
results in decreased cortisol and mineralocortoids
and INCREASED sex hormones
what enzyme is commonly deficient in patients with congenital adrenal hyperplasia?
21-hydroxylase
how does congenital adrenal hyperplasia present in females?
Virilisation of external genitals
clitoral hypertrophy
variable fusion of labia
how does congenital adrenal hyperplasia present in males?
enlarged penis and pigmented scrotum (precocious puberty)
describe the presentation of a salt-losing adrenal crisis in males
- weight loss
- vomiting
- hypotonia and circulatory collapse
how is congenital adrenal hyperplasia diagnosed?
raised levels of 17 alpha-hydroxy-progesterone in blood
how is salt-losers adrenal crisis in CAH diagnosed?
- low plasma sodium
- high plasma potassium
- metabolic acidosis
- hypoglycaemia
how is salt-losers adrenal crisis managed?
sodium chloride, glucose, IV hydrocortisone
describe the long-term management of congenital adrenal hyperplasia
- lifelong glucocorticoids (hydrocortisone)
- mineralocorticoids (fludrocortisone)
- monitor growth, skeletal maturity and plasma androgen levels