Paediatric Haem Flashcards
What FBC cell counts are higher in neonates?
HIGH WCC, neutrophils, lymphocytes
HIGH Hb, MCV
What haemoglobin type is higher in neonates?
HbF
What is G6PD like in neonates?
HALF the quantity of adults
What are causes of neonatal polycythaemia?
Twin-twin transfusion
Intreauterine hypoxia
Placental insufficiency
What are causes of foetal anaemia?
twin-twin transfusion
foetal-maternal transfusion
Parvovirus infection
Haorrhage from cord/placenta
What chromosomal disease predisposes to congenital leukaemia?
Downs
What occurs to congenital leukaemia after first few months of life?After a few years?
Remits spontaneously
Then relapses after a few years
What genotype is sickle cell anaemia=
HOMOZYGOUS HbS gene
How do you test for sickle cell anaemia in babies?
Guthrie test (heelprick)
How does distribution of red bone marrow in children affect sickle cell symptoms ?
Children will have bone pain due to infarct all the way down to fingers/toes
Due to red bone marrow in these bones
Adults instead only have red bone marrow in central skeleton > pain in that
What is the timeline of what happens to the spleen in sickle cell?
Splenic sequestration
Hyposplenism
Increased infection risk
What disease are sickle cell/hyposplenic children more susceptible to?
PARBOVIRUS B19
What blood cell features does parvovirus present with?
APLASTIC ANAEMIA
anaemia + low reticulocytes
How do you prevent pneumococcal infection in sickle cell children?
Vaccination + penicillin
When in life does beta thalassameia become symptomatic?
after first 6m of life
