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Path - Haematology > Lymphoma 2 > Flashcards

Lymphoma 2 Flashcards

1
Q

What cell type occurs classically with Classical HL?

A

Reed Sternberg cells

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2
Q

What does painless lymphadenopathy cause clinically if it is superficial?

A

Palpable lymph nodes

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3
Q

What does painless lymphadenopathy cause clinically if it is deep?

A

Obstructive symptoms

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4
Q

What are the types of Classical Hodgkin Lymphoma that can occur ?

A

Lymphocyte rich/depleting
Mixed cellularity
Nodular sclerosing

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5
Q

How does HL progress?

A

Starts in 1 lymph node

progresses continuously through lymph node route

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6
Q

What is the fastest growing human cance3r?

A

Burkitts (NHL)

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7
Q

How do you treat NHL?

A

More complex than with HL
Chemotherapy
Monitor (watch and wait)
Antibiotic eradication *H pylori(

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8
Q

How does curability relate to aggression of lymphoma?

A

The more aggressive the more CURABLE

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9
Q

What is tx of DLBCL

A

R CHOP

Rituximab 
Cyclophosphamide
Doxorubicin 
Vincristine 
Prednisolone
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10
Q

What is the translocation in follicular NHL?

A

t(14,18)

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11
Q

What is the gene overexpressed in follic NHL?

A

Bcl2

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12
Q

What is treatment for follic NHL?

A

R CVP

Rituximab Cyclophosphamide Vincristine Prednisolone

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13
Q

What tissue is involved in a marginal zone NHL?

A

EXTRANODAL lymphoid tissue

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14
Q

What are examples diseases causing MZL?

A

Sjogrens = parotid lymphoma
H pylori = gastric MALToma
Hashimotos thyroiditi = thyroid
Psittaci infection = lacrimal gland

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15
Q

What is the usual number/letter presentation of MZL

A

Stage 1 E (single site, extranodal)

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16
Q

What are findings of CLL?

A

lymphocytosis
Smear cel;;s
Normocytic normochromic anaemia
Thrombocytopoenia

17
Q

What kind of cancer is CLL (indolent or aggressive)???

A

INDOLENT

18
Q

What antigen expression on B cells confirms CLL?

A

CD5 POSITIVE
CD19 negative
*CD5 is normally present only on immature B cells

19
Q

What is supportive tx for CLL?

A

VACCINATION (flu, pneumococcus) - NOT VZV because live

Anti-infective prophylaxis &tx (acyclovir)

20
Q

what chemo is given for TP53 intact CLL?

A

FCR

21
Q

What therapy is given for TP53/17p deletion CLL?

A

Ibrutinib (bruton TK inhibitor)

Venetoclax (anti Bcl2)

Path - Haematology (17 decks)

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