Paediatric Anaesthesia Flashcards
The provision of safe anaesthesia for the paediatric patient requires a clear understanding of the ________,________,__________ and __________ differences children and adults.
psychological, anatomic, physiological and pharmacologic
Span from Newborn to adolescent
Neonates –__________ of life. May be preterm
Infants – ______ to _________
Preschool -__-____yrs
Schoolage – ___-____ yrs
first 28 days
1 month to 1 year
1-5
5-12
Neonates further classified as
Full term
Pre-term <____wks
Extreme preterm <____ wks
Post-term >____ wks
Low Birth Weight < ____g
Extremely Low Birth Weight <______g
37
28
41
2500
1000
Postconceptual age = ______ + _______
GA + PNA
Anatomical differences
Anatomy of airway predisposes to obstruction and difficult intubation.
- ________ head, ________ neck, ________ neck muscles, ___ AP diameter→ difficult positioning.
- ________ nares → easily obstructed e.g ________ - ________ tongue readily obstructs ________ → obligate _____________
- Anterior, high larynx C___- C___
- (short or long?), ___-shaped epiglottis at _____ angle
large ; short ;underdev
↑; Small ;catarrah
large ;oropharynx ; nasal breathers
C2- C4
long ; U ; 450
Pediatric
_______ shaped larynx with ______ as the narrowest part
The ________ is narrowest part in adults
Funnel; cricoid
glottis
(Anterior or Posterior?) , (low or high?) larynx C___- C__ (C__- C__ in adults)
(Short or Long?), _____ epiglottis
Soft tracheal cartilages
Thin lining of airway which easily gets damaged.
Anterior ; Hugh
C2- C4
C5- C6
Long; floppy
Paeds
(Vertical or Horizontal?) ribs with loss of ____________ movt does not contribute to resp mechanics→ _________ breathers
Large liver pushes up and flattens diaphragm → ________ tidal volume
____________ intercostal muscles
___________________ of bronchi -___0
Horizontal ; bucket-handle
diaphragmatic ; fixed
Poorly developed
Equal bifurcation
55
Anatomical differences
CNS
Spinal cord terminates at _______
Dural sac terminates at _____ in neonates
CVS
_____ veins, extensive _________→ ________ cannulation
L3/L4
S3
Tiny; subcut fat
difficult
Physiological differences
Few alveoli → _______
↓FRC, closing volume encroaches on FRC
→ easily ________ with ____
↑alveolar ventilation will req ↑ ________________ 6-8ml/kg/min to meet demands
Response to hypercapnia and hypoxaemia →____________
Surfactant produced at ____wks GA
V/Q mismatch
hypoxic with apnoea
O2 consumption
respiratory depression
36
Physiological Cardiovascular
Easily reverts to _______ circulation
↑ cardiac output ←↑_____ reqs ↑ ________
↓ myocardial contractile tissue→ less able to ↑ ___________. Thus Cardiac output is _________ dependent
Normal heart rate – _____-_____ bts/min (neonates)
Predominant _______ innervation of heart ↓ ____- activity → _______ and _______
foetal ; BMR ; perfusion
stroke volume ; heart rate
130 -160
parasym ; sym
low BP ; PVR
Haematological
Blood volume
– preterm ____-____ mls/kg
- neonate – ____mls/kg
- infant - ____mls/kg
- child - ___mls/kg
Hb ____ – ___ g/dl at birth
- ‘physiological anaemia’
Hb____ predominant till ________ . ↓2,3 DPG, Lt shift of ODC
preterm 95 -100 mls/kg
- neonate – 90mls/kg
- infant - 85mls/kg
- child - 80mls/kg
Hb 18 – 21 g/dl at birth
HbF predominant till 6 months
Pardiatric Neonate
(Mature or Immature?) CNS
___________ myelination →_____ conduction time but _______ interneuron distance for impulse to travel
Blood-brain barrier is (more or less?) permeable
Impaired autoregulation → intraventricular hmg
Immature
Incomplete; slower
shorter; more
Paeds Temperature Control
High ______ area : _______ ratio → _____ loose heat esp from _______
Immature __________ centre
Lack of ___________
Unable to ________
Cutaneous vessels do not _________
Non-shivering thermogenesis → hypoxia, acidosis, hypoglycaemia
Thermoneutral temperature (____oC prems, ____oC neonates)
body surface area : body weight
rapidly ; head
thermoregulatory ; subcutaneous fat
shiver ; vasoconstrict
34oC ; 32oC
Paeds Renal /Fluid Balance/ Hepatic
TBW = _____% of body wt
↑ ECF (75%) →↑__________ of drugs
→ more accessible to _______
________ renal function, therefore unable to
handle large fluid or Na loads.
Limited ____________________ → easily become hypoglycaemic
90
volume of distribution; fluid losses
Immature; carbohydrate stores
Paeds pharmacology
↑ cardiac output → faster ____________
↑ ECF → ↑__________________ of highly
ionised drugs e.g muscle relaxants
Immature liver enzymes → ↓ _______________ especially __________
Immature renal fxn → ↓_____________
MAC – ___es with ____ing age till ____/12 (except _____)
↑ sensitivity to induction agents – immature ________
MR - ↑sensitivity, but ↑ vol of distr → dose
circulation time
vol of distribution ; drug metabolism
morphine; drug excretion
↑; ↑; 6; Sevo; BBB