pack 2

Question 1

What is the relation between B6/Pyridoxal phosphate and isoniazid TB drug?

Answer 1

Isoniazid (INH) is a tuberculosis drug
Similar to B6 structure
Forms inactive pyridoxal phosphate
Result in B6 deficiency
Must supplement B6 when taking INH

Question 1

What is another name for B12?

Answer 1

Cobalamin

Question 2

What is cobalamin/B12 used for?

Answer 2

It is used for Thymdine synthesis

used in metabolism of homocysteine (methionine metabolism)

Question 3

What happens bc Deficiency of B12?

Answer 3

Deficiency of B12: ↓ DNA synthesis (megaloblastic anemia)

Question 4

What is another name for Vitamin C?

Answer 4

Ascorbic acid

Question 5

What does Vitamin C/ Ascoribic acid do in relation with fe+2?

Answer 5

Increases its absorbtion in the intestine by keeping it in the reduced state

Question 6

How is Vitamin C/ascorbic acid related to collagen formation?

Answer 6

Required for collagen synthesis
essential for hydroxylation of proline and lysine
Cofactor for prolyl and lysyl hydroxylases
addition of hydroxyl group allows for hydrogen bonding between fibers
without cross-linking triple helix shape cannot form

Question 7

What are the symptoms of scurvy?

Answer 7

fragile blood vessels
swollen bleeding gums
perifollicular hemorrhage
poor wound healing
easy bruising (ecchymosis)

Question 8

What type of reactions is bitotin involved in?

What inhibts it?

Answer 8

Involved in ATP dependent carboxylation reactions: pyruvate carboxylase
Produced by gut microflora
Deficiencies are rare
Consuming 6 raw eggs a day can cause deficiencies due to the presence avidin (biotin binding protein)

Question 9

Are Water-soluble vitamins stored in the body?

Answer 9

No, except for folate and B12