p53 and Cancer Flashcards
1
Q
What is p53?
A
A tumor suppressor, critical for normal cell growth and tumor prevention
2
Q
What activates p53?
A
endogenous and exogenous stressors
3
Q
What happens when p53 is activated?
A
It is triggered to further regulate a series of cellular responses necessary for homeostasis maintenance
4
Q
What are the advantages of the activation of p53 in response to stressors?
A
Critical for normal cells to survive and protect themselves from cancer development
5
Q
What happens when p53 is mutated?
A
Loss of function necessary for tumor suppression & gain of functions necessary for tumor growth
6
Q
Homeostasis?
A
refers to the ability of an organism or system to maintain internal stability
