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CC LEC 2 > P5: CK, LD, GGT, G6PD, ACE, 5'N, CHE, ALD > Flashcards

P5: CK, LD, GGT, G6PD, ACE, 5'N, CHE, ALD Flashcards

1
Q

CK

● MW: ____________

A

82,000 Da

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2
Q

Associated with ATP regeneration in contractile or transport
system (constant concentration of ATP in the muscle needed for any sudden burst of exercise)

A

Creatine Kinase

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3
Q

● Goal of CK is to create ATP without using ____________

A

mitochondria

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4
Q

● ________________ serves as a storage of energy

A

Phosphocreatine

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5
Q

● CK will form phosphocreatine from ________and ________

A

creatine and ATP

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6
Q

Creatine kinase 3 isoenzymes
1. ________________
2. ____________
3. ____________

A

CK-MM - skeletal
CK-MB - heart
CK-BB - brain

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7
Q

last to migrate in CK isoenzymes

A

CK MM

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8
Q

first to migrate in CK isoenzymes

A

CK BB

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9
Q

CK-Mi

○ MW: ___________

A

350, 000

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10
Q

○ bound to the exterior surface of the inner
mitochondrial membranes of muscle, brain, and liver

A

● CK-Mi

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11
Q

○ big molecules; difficult for kidney to filter

A

● Масго-CK

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12
Q

______________ is commonly tested as part of cardiac panel to
diagnose AMI

A

CK-MB

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13
Q

○ ____________ is not measured in the lab

A

Total CK

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14
Q

MYOCARDIAL INFARCTION (MI)
● Rise: within _____________ after the onset
● Peak: ___________
● Return to normal: within __________hours

A

Rise: within 4-8 hours after the onset
● Peak: 12-24 hours
● Return to normal: within 48-72 hours

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15
Q

○ ____________is the best cardiac marker

A

Troponin

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16
Q

● Catalyzes the interconversion of lactate to pyruvate and vice
versa

A

lactate dehydrogenase

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17
Q

_______________ is not diagnostically significant since it is widely distributed in the body; increase would not confirm anything

A

Lactate dehydrogenase

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18
Q

Coenzyme of LD

A

NAD+

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19
Q
  • rely on production of lactate to be able
    to perform anaerobic glycolysis
A

Erythrocytes

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20
Q

The role of GGT is either to store or create
__________when it is needed

A

glutathione

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21
Q

Glutathione is a tripeptide composed of: ______________, ____________, ____________

A

cysteine, glutamine, and glycine.

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22
Q

____________ and ___________- anti seizure drugs

A

Phenobarbital and phenytoin

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23
Q

_____________ is a blood thinner

A

warfarin

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24
Q

_________, __________, ___________called enzyme
inducers because they trigger the release of enzymes
in the liver once they are metabolized

A

warfarin, phenobarbital, phenytoin

25
Q

● If ALP is only increased, it is a ___________

A

Bone disease

26
Q

If both are increased then it is a ____________

A

Liver disease (bile duct)

27
Q

_______________ - is the product of GGT reaction

A

Para-Nitroaniline

28
Q

The more Para-Nitroaniline, the more ___________

A

GGT present

29
Q

Catalyzes the oxidation of glucose-6-phosphate or
6-phosphogluconolactone

A

Glucose 6 Phosphate dehydrogenase

30
Q

● Reaction is more important in the pentose-phosphate shunt of glucose metabolism wit the ultimate production of NADPH

A

Glucose 6 Phosphate dehydrogenase

31
Q

● Maintain NADPH in reduced form

A

Glucose 6 Phosphate dehydrogenase

32
Q

● Low G6PD = low NADPH = ______________

A

low reduced glutathione hemolysis

33
Q

● ____________ is our body’s natural antioxidant

A

Glutathione

34
Q

_____________ is used to measure if it is high because the
enzyme is only released in the circulation if it is high

A

serum

35
Q

___________________is used to measure deficiency

A

Red cell hemolysate

36
Q

Angiotensin Converting enzyme other name is _________ and _____________

A

Kininase II and Peptidyl-Dipeptidase A

37
Q

● ____________detects low blood pressure

A

RAAS

38
Q

RAAS pathway starts with _____________ and ___________

A

renin (from kidneys) and
Angiotensinogen (from liver)

39
Q

○ Catalyzes conversion of angiotensinogen to
angiotensin 1

A

Renin

40
Q

○ Catalyzes conversion of angiotensin 1 to angiotensin
2 which increases blood pressure by secreting
Antidiuretic hormon

A

● ACE (from lungs)

41
Q

○ ACE inhibitor

A

● Captopril

42
Q

● Tissue-bound, with much lower levels circulating in plasma

A

ACE

43
Q

Rich in ACE

A

● Lungs (main source) and Testes

43
Q

Predominantly found in endothelial cell membranes throughout
the body

A

ACE

44
Q

○ Used to measure ACE

A

Hippuric acid

45
Q

Substrate of 5’N

A

Adenosine monophosphate and
guanosine monophosphate (nucleotides)

46
Q

Widely distributed in the body, predominantly attached to cell
membranes (like ALP and GGT)

A

5’N

47
Q

5’N

○ Increase = __________
○ Normal = ____________

A

○ Increase = Liver Disease
○ Normal = Bone Disease

48
Q

____________ or ______________is produced by the
liver and hydrolyzes choline esters

A

Pseudocholinesterase or butyrylcholinesterase

49
Q

○ Organophosphate Insecticides

A

PseudoChE

50
Q

Useful in organophosphate exposure and poisoning

A

● AChE

51
Q

○ Qualitative analysis in amniotic fluid may be useful in
the diagnosis of __________ (normally absent
in Amniotic Fluid)

A

neural tube defects

52
Q

D-fructose-1,6-bisdisphosphate
D-glyceraldehyde-3-phosphate-lyase

A

aldolase

53
Q

hemolysate of washed RBC

A

True ChE

54
Q

Serum

A

PseudoChE

55
Q

Pseudocholinesterase

Substrate: _______________
Product: _____________

A

● Substrate: acetylthiocholine ester
● Released thiocholine which will interact with Ellman’s reagent
● Product: 5-mercapto-2-nitro benzoic acid

56
Q

method use in pseudocholinesterase

A

Ellman’s method

57
Q
A

CC LEC 2 (15 decks)

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