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Blood Bank Test 3a > P and Globoside Blood Group System, Globoside Collection > Flashcards

P and Globoside Blood Group System, Globoside Collection Flashcards

1
Q

P1 was found by which duo?

A

Landsteiner and Levine

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2
Q

These antigens have a relationship to the P blood group system

A

P1, P, Pk, and LKE

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3
Q

This antigen is in the P blood group system (003)

A

P

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4
Q

This antigen is in the Globoside blood group system (028)

A

P1

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5
Q

These antigens are in the Globoside blood group collection

A

Pk and LKE

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6
Q

The P blood group system is designated by ISBT number

A

003

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7
Q

The Globoside blood system is designated by ISBT number

A

028

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8
Q

Antigens produced by genes are _______ or GSLs, in the P system (003)

A

glycosphinogolipids (GSLs)

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9
Q

In the P blood group system (003), glycosphinogolipids (GSLs) are linked to ____ on the cell membrane.

A

sphinegolipids

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10
Q

P1
Frequency:
Antigens:
Antibody:

A

P1
Frequency: 75%
Antigens: P1, P, Pk
Antibody: none

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11
Q

P2
Frequency:
Antigens:
Antibody:

A

P2
Frequency: 25%
Antigens: P, Pk
Antibody: Anti-P1

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12
Q

p
Frequency:
Antigens:
Antibody:

A

p
Frequency: < 1%
Antigens: none
Antibody: anti-P1, anti-P

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13
Q

P1k
Frequency:
Antigens:
Antibody:

A

P1k
Frequency: < 1%
Antigens: P1, Pk
Antibody: Anti-P

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14
Q

P2k
Frequency:
Antigens:
Antibody:

A

P2k
Frequency: < 1%
Antigens: Pk
Antibody: anti-P1, anti-P

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15
Q

The P1 phenotype has these antigens present

A

P1
P
Pk

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16
Q

The P1 phenotype antigens can be found on fetal RBCs at __ weeks, but weekens with gestational age

A

12 weeks

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17
Q

It takes __ years for P1 antigens to be fully expressed

A

7 years

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18
Q

The P2 phenotype has these antigens

A

P and Pk (lack P1)

19
Q

This phenotype is more prevelant in Cambodians and Vietnamese

A

P2

20
Q

What is the null phenotype of the P (003) and GLOB (028) blood group system?

A

p

21
Q

The null phenotype, p, lacks these antigens (rare)

A

P
P1
Pk

22
Q

The P1k phenotype has these antigens (rare)

A

P1
Pk
(lacks P)

23
Q

The P1k phenotype has this antibody present in serum (rare)

A

Anti-P

24
Q

The P2k phenotype has these antigens (rare)

A

Pk

25
Q

The P2k has these antibodies present in serum

A

anti-P

anti-P1

26
Q

The antibody is found in the sera of P2 individuals

A

anti-P1

27
Q

Anti-P1 is usually what class of antibody?

A

IgM

28
Q

This antibody may rarely cause in vitro hemolysis by binding complement

A

Anti-P1

29
Q

This antibody does not cause HDNF because the antigen is poorly developed on the newborn.

A

Anti-P1

30
Q

Anti-P1 is ___ reactive, so it is usually clinically insignificant.

A

cold reactive

31
Q

This antibody is associated with parasitic worm infections

A

Anti-P1

32
Q

This antibody is neutralized with soluble P1 substances found in hydatid cyst fluid (usually found in tape work)

A

Anti-P1

33
Q

Anti-P is found in the serum of __, __ and __ individuals.

A

P1K
P2K
p

34
Q

Anti-P is significant in transfusions due to

A

hemolysis

35
Q

The Donath-Landsteiner test demonstrates hemolytic nature of

A

Anti-P

36
Q

Anti-P is associate with spontaneous abortions in these women

A

p

Pk

37
Q

This antibody attaches to RBCs in cold an lyses them as they warm up.

A

Anti-P

38
Q

This antibody is an IgG autoantibody in paroxysmal cold hemoglobinuria (PCH).

A

Anti-P

39
Q

This antibody causes a complex immune response in p individuals, HTR, rarely HDN

A

Anti-PP1Pk

40
Q

Pk antigens have receptors for toxins produces by

A

S. dysenteriae

E. coli

41
Q

P antigens have receptors for

A

parvo-B19 virus

42
Q

Individuals lacking antigens appear to be naturally resistant tp

A

S. dysenteriae
E. coli
parvo-B19

43
Q

This substance is available to assist in ruling out nuisance anti-P1 activity.

A

P1 Neutralization

Blood Bank Test 3a (7 decks)

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