P and Globoside Blood Group System, Globoside Collection Flashcards
P1 was found by which duo?
Landsteiner and Levine
These antigens have a relationship to the P blood group system
P1, P, Pk, and LKE
This antigen is in the P blood group system (003)
P
This antigen is in the Globoside blood group system (028)
P1
These antigens are in the Globoside blood group collection
Pk and LKE
The P blood group system is designated by ISBT number
003
The Globoside blood system is designated by ISBT number
028
Antigens produced by genes are _______ or GSLs, in the P system (003)
glycosphinogolipids (GSLs)
In the P blood group system (003), glycosphinogolipids (GSLs) are linked to ____ on the cell membrane.
sphinegolipids
P1
Frequency:
Antigens:
Antibody:
P1
Frequency: 75%
Antigens: P1, P, Pk
Antibody: none
P2
Frequency:
Antigens:
Antibody:
P2
Frequency: 25%
Antigens: P, Pk
Antibody: Anti-P1
p
Frequency:
Antigens:
Antibody:
p
Frequency: < 1%
Antigens: none
Antibody: anti-P1, anti-P
P1k
Frequency:
Antigens:
Antibody:
P1k
Frequency: < 1%
Antigens: P1, Pk
Antibody: Anti-P
P2k
Frequency:
Antigens:
Antibody:
P2k
Frequency: < 1%
Antigens: Pk
Antibody: anti-P1, anti-P
The P1 phenotype has these antigens present
P1
P
Pk
The P1 phenotype antigens can be found on fetal RBCs at __ weeks, but weekens with gestational age
12 weeks
It takes __ years for P1 antigens to be fully expressed
7 years
The P2 phenotype has these antigens
P and Pk (lack P1)
This phenotype is more prevelant in Cambodians and Vietnamese
P2
What is the null phenotype of the P (003) and GLOB (028) blood group system?
p
The null phenotype, p, lacks these antigens (rare)
P
P1
Pk
The P1k phenotype has these antigens (rare)
P1
Pk
(lacks P)
The P1k phenotype has this antibody present in serum (rare)
Anti-P
The P2k phenotype has these antigens (rare)
Pk
The P2k has these antibodies present in serum
anti-P
anti-P1
The antibody is found in the sera of P2 individuals
anti-P1
Anti-P1 is usually what class of antibody?
IgM
This antibody may rarely cause in vitro hemolysis by binding complement
Anti-P1
This antibody does not cause HDNF because the antigen is poorly developed on the newborn.
Anti-P1
Anti-P1 is ___ reactive, so it is usually clinically insignificant.
cold reactive
This antibody is associated with parasitic worm infections
Anti-P1
This antibody is neutralized with soluble P1 substances found in hydatid cyst fluid (usually found in tape work)
Anti-P1
Anti-P is found in the serum of __, __ and __ individuals.
P1K
P2K
p
Anti-P is significant in transfusions due to
hemolysis
The Donath-Landsteiner test demonstrates hemolytic nature of
Anti-P
Anti-P is associate with spontaneous abortions in these women
p
Pk
This antibody attaches to RBCs in cold an lyses them as they warm up.
Anti-P
This antibody is an IgG autoantibody in paroxysmal cold hemoglobinuria (PCH).
Anti-P
This antibody causes a complex immune response in p individuals, HTR, rarely HDN
Anti-PP1Pk
Pk antigens have receptors for toxins produces by
S. dysenteriae
E. coli
P antigens have receptors for
parvo-B19 virus
Individuals lacking antigens appear to be naturally resistant tp
S. dysenteriae
E. coli
parvo-B19
This substance is available to assist in ruling out nuisance anti-P1 activity.
P1 Neutralization
