Lewis Blood Group System

Question 1

The Lewis Blood Group System is designated by ISBT as number

Answer 1

007

Question 2

The LE locus is found on chromosome…

Answer 2

19

Question 3

These Lewis antigens are belived to be amorph

Answer 3

Le

le

Question 4

lele gene

Answer 4

Le(a-b-)

Question 5

What are the two main antigens of the Lewis Blood Group System (007)?

Answer 5

Le^a

Le^b

Question 6

What are the possible phenotypes of the Lewis blood system (007)?

Answer 6

Le(a+b-)
Le(a-b+)
Le(a-b-)
Le(a+b+) very rare

Question 7

Nonsecreator Le genes make these antigens

Answer 7

Le^a

Question 8

Secretor Le genes make these antigens

Answer 8

Le^b

Question 9

This antigen is found on all RBCs which are Le(a+b-) and Le (a-b+)

Answer 9

Le^ab

Question 10

How are Lewis (007) antigens expressed at birth?

Answer 10

Minimal

Question 11

Lewis blood group (007) antigens are NOT membrane bound. They are

Answer 11

adsorbed from plasma onto RBCs (glycolipids)

Question 12

Lewins blood group antigens are carried by

Answer 12

glycolipids

Question 13

The level of Le antigens detectable on RBCs are influenced by

Answer 13

ABO genes inherited

Question 14

The Le gene produces 1-4 fucosyltransferase to add frucose to _____ structures only.

Answer 14

Type 1

Question 15

These antigens are found in both plasma and secreations

Answer 15

Lewis antigens

Question 16

Lewis substances on type1 chains in plasma and in secreations are the same, but the ____ molecule is different

Answer 16

Carrier molecule

Question 17

What are the two Lewis Blood Group (007) thaqt interact but are at different loci?

Answer 17

Se(FUT2)

Le(FUT3)

Question 18

This gene enables A, B, and H, antigens to be secreted by coding for the enzyme …

Answer 18

1-2 fucosyltransferase

Question 19

The inheritance of at least one FUT2 gene (Sese, SeSe) allows for

Answer 19

ABH antigen secretions