Oxybutynin Chloride (oral) (Urinary Bladder Modifier)

Question 1

What are the brand names of Oxybutynin Chloride (oral)?

Answer 1

Ditropan & Ditropan XL

Question 2

What are the available tablet strengths of Ditropan?

Answer 2

5mg

Question 3

What are the available XR tablet strengths of Ditropan XL?

Answer 3

5mg, 10mg, 15mg

Question 4

What is the available syrup strength of Oxybutynin Chloride?

Answer 4

5mg/5mL (1mg/mL)

Question 5

What other dosage form is available for oxybutynin Cl?

Answer 5

Topical Patch Formulation

Question 6

What is the FDA approved indication for Oxybutynin Cl? What is the dose for this indication?

Answer 6

For the relief of the symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder.

1 5mg immediate release tablet given 2-3 times daily. Maximum of 20mg/day

Question 7

What dose of Ditropan is approved for the treatment of overactive bladder with symptoms of urge urinary incontenge, urgency, and frequency?

Answer 7

Start with 1 5mg XR tablet daily. May increase at weekly intervals to a maximum of 30mg/day

Question 8

What age is oxybutynin recommend for?

Answer 8

Not recommend for children under the age of 5. (Recommended for ages 5 & up)

Question 9

What is the mechanism of action of Oxybutynin?

Answer 9

Oxybutynin inhibits the muscarinic action of acetylcholine on smooth muscle.

Question 10

What are the drug interactions of Ditropan?

Answer 10

May decrease the effects of phenothiazines and haloperidol. May cause tar dive dyskinesia when used with haloperidol. Additive effects may be seen with other anticholinergic agents.

Question 11

What are the contraindications of Oxybutynin Cl?

Answer 11

• Contraindicated in uncontrolled narrow-angle glaucoma, urinary retention, and gastric retention.
• Use with caution in patients with renal or liver impairment, gastrointestinal obstruction, ulcerative colitis, intestinal atony, and myasthenia gravis.
• Use with caution in patients with gastroesophageal reflux disease and in those taking drug that can cause or exacerbate esophagitis (such as biphosphonates)
• Heat prostration can occur in the presence of high environmental temperature
• Pregnancy Category B

Question 12

What are the adverse effects of Oxybutynin?

Answer 12

Dry mouth, drowsiness, confusion, agitation, blurred vision, diarrhea, nausea. Side effects may decrease with prolonged use.

Question 13

What should the RPh tell the patient?

Answer 13

• Avoid prolonged exposure to hot weather
• May cause drowsiness. Use caution while operating machinery or when mental alertness is required.
• If a dose is missed, take it ASAP. If the time is closer to next dose than missed dose, skip the missed dose. Do NOT double doses.
• Swallow extended-release tablets whole. Do not crush, split, chew
• The semipermeable membrane tablet shell of the extended-release tablet passes through the GI tract intact and may be found in the stool