Oxidative Phosphorylation Flashcards
Catabolic Pathway Purposes
Breakdown larger molecules into smaller building units, release and storage of energy in high-energy molecules
cataobolic pathway cofactors
reduced cofactors (NADH/FADH2)
Catabolism Ox or Red
Oxidative. Metabolites are oxidized whiel cofactors are reduced.
Re-oxidation of cofactors (catabolism)
used to generate ATP
Oxidative Phsophorylation
separate but connected process, linked through a proton gradient across the mitochondrial membrane
Oxidation
oxidation of reduced cofactors (NADH, FADH2) and reduction of molecular oxygen
Phosphorylation
phosphorylation of ADP to ATP
Overview of oxidative phosphorylation
reduced cofactors generated form glycolysis -> electron teransport chain -< prton gradient -> ATP synthesis
Location of oxidative phosphorylation
Inner Mitochondrial membrane
how many protons do you need for ATP synthesis (approx)
3
Two portions of ATP synthase
F0 and F1
Fo
Transmembrane portion, protons pass through, triggers conformation change in F1
F1
catalytic protion, synthesis of ATP from ADP and Pi
What does the rate of ATP synthase determine
Proton movement and (ultimately) oxygen consumption