Glycolysis Flashcards

1
Q

Glycolysis Cat or Ana

A

Catabolic pathway

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2
Q

Glycolysis Overview

A

1 molecule of glucose into 1 molecule of pyruvate, generates ATP directly and NADH from oxidation of metabolites.

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3
Q

glucose to pyruvate

A

glycolysis

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4
Q

pyruvate to glucose

A

gluconeogensis

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5
Q

Does glycolysis require O2

A

NO, it is anaerobic
(can operate anaerobically)

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5
Q

stage 1

A

energy investment (hexose)

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6
Q

stage 2

A

energy pay off (triose)

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7
Q

hexokinase catalyzed rxn

A

irreversable, exergonic, coupled, phosphate transfer, regulated (but not rate limiting)

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8
Q

PFK-1 cataylzed rxn

A

irreversable, exergonic, coupled, phosphate transfer, regulated, rate limiting

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9
Q

glyceraldyehyde-3-phosphate dehydrogenase cat. rxn

A

oxidation, reversible, “energy capture”

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10
Q

1,3-BPG to 3-phosphoglycerate

A

reverisble, coupled, “energy capture” step, substrate-level phosphorylation

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11
Q

pyruvate kinase cat. rxn

A

irriversible, coupled, substarate level phosphorylation, regulated, energy capture step

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12
Q

4 things affecting flux rate
(general metabolic processes)

A

substrate availability, aleration of enzyme activity, alteration of amount of enzyme, compartmentation

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13
Q

regulation in glycolysis

A

substrate availability (glucose import), and enzyme regulation (Hexiokinase, PFK-1, Pyruvate kinase)

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14
Q

Aerobic reoxidation of NADH back to NAD+

A

oxidative phosphorylation

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15
Q

Anareobic reoxidation of NADH to NAD+

A

Pyruvate reduction (ethanol, lactate formation)

16
Q

why does pyruvated get converted to lactate

A

to regentate NAD+ to NADH

17
Q

what transport pyruvate into the mitochdria matrix

A

pyruvate translocase

18
Q

PDH regulation (dephosphorylation)

A

swithces activoty off via kinase

19
Q

PDH regulation (phosphorylation)

A

activates the complex via a phosphotase

20
Q

PDH regulation substrate activation

A

NAD+ and HS-CoA

21
Q

PDH regulation substarte inhibition

A

NADH and acety;-CoA