Oxazolidinones (Linezolid)

Question 1

What is the SOA for Linezolid?

Answer 1

Resistant Gram (+) Bacteria such as:
Methicillin-resistant Staphylococcus aureus (MRSA)
Vancomycin-resistant Enterococci (VRE)
Listeria

Linezolid is an alternative to Daptomycin for treating infections caused by VRE.

Question 2

What is the MOA of Linezolid?

Answer 2

Inhibits protein synthesis by binding to the 23S ribosomal RNA which prevents the initiation complex. This unique mechanism reduces the likelihood of cross-resistance with other antibiotics.

Question 3

What is important lab work to monitor on Linezolid?

Answer 3

Weekly monitoring of CBC due to risk of thrombocytopenia, when the drug is used for more than 10 days.

Question 4

What drug-drug interactions are important to monitor with Linezolid?

Answer 4

SSRIs, MAOIs, and tyramine-containing foods can cause serotonin syndrome (confusion, hyperreflexia, hyperthermia)

Question 5

What are tyramine containing foods?

Answer 5

Aged cheeses, smoked meats, fermented products