Overview of Renal Pathophys Lecture Flashcards
Azotemia definition
elevated BUN and Creatinine levels in blood usually due to decreased GFR
Uremia definition
excess urea and nitrogenous waste in blood = can be toxic! - can occur due to metabolic and endocrine alterations
Definition of Acute Kidney Disease
ABRUBT decrease in GFR or CrCl
How to classify Acute Chronic Kidney disease
RIFLE classification
what does RIFLE classification stand for
Risk Injury Failure Loss of Kidney Function End-Stage Kidney Disease
Types of anatomical names for acute kidney injury/malfunction
- pre-renal
- intrinsic
- post-renal
If the Acute chronic kidney disease is caused by a pre-renal malfunction - what does it mean?
decreased renal blood flow
If the Acute chronic kidney disease is caused by a intrinsic malfunction - what does it mean?
structure within kidney is damaged
If the Acute chronic kidney disease is caused by a post-renal malfunction - what does it mean?
obstruction within urine collection system
Definition of Chronic Kidney Disease
progressive loss of function - gradual replacement of normal kidney architecture with parenchymal fibrosis
4 possible disease states that can lead to chronic kidney disease
Diabetes Mellitus; Initial pathogenic injury; Hyperlipidemia; Systemic HTN
what is glomerulosclerosis
glomerulus is changing to fibrotic tissue (
what is the normal GFR level range
90 to 120 mL/min/1.73 m^2
Definition of Hemodialysis
perfusion of blood and dialysate on opposite sides of semipermeable membrane - remove substances from blood by diffusion = excess plasma water is removed via ultrafiltration
Peritoneal dialysis
permanent catheter - peritoneal membrane acts as semipermeable membrane - osmotic pressure is generated by various dextrose and icodextrin concentrations
What components can make up the osmotic pressure in peritoneal dialysis
dextrose; icodextrin
What is analgesic nephropathy
large doses of ASA and APAP can cause it
Nephritis = Glomerulonephritis = GN can be divided into what two groups
Primary and secondary
Secondary GN is associated with what?
systemic diseases - like SLE, HTN, diabetes
Pathogenesis of Glomerular Diseases = __________ reaction
immune
3 pathogenesis/immune reactions for glomerular diseases
1 - antibody - associated injury
2 - Cell mediated immune
3 - other mechanisms of glomerular injury
Nephrotic vs Nephritic Syndrome
Nephrotic - protein leakage only
Nephritic - protein AND RBC leakage
3 major types of Glomerular syndromes
nephrotic syndrome; nephritic syndrome; chronic glomerulonephritis
Common signs/symptoms of Nephrotic syndrome
- proteinuria
- hypoalbuminemia
- edema
- hyperlipidemia/lipiduria
Common signs/symptoms of Nephritic syndrome
- hematuria
- oliguria
- azotemia
- HTN
APKD:
inherited mutation of ________ gene _______ which gives rise to the protein ________
Dominant; PKD1 and PKD2; polycystein
Pathogenesis of APKD
Abnormal cysts formation in both kidneys; ultimately destroys intervening parenchyma; intermittent gross hematuria; HTN and urinary infection
Autosomal Recessive (______) Polycystic Kidney disease: Mutation in ______ which makes ______ (_______)
childhood; PKHD1; fibrocystin; polyductin