Ovarian PRP

Question 1

What is ovarian PRP?

Answer 1

Autologous platelet rich plasma involves injecting of a patients own PRP into the ovary in close proximity to the primordial follicle pool.
Used in women with dimished ovarian reserve.

Question 2

Theory behind benefit - physiology, target group

Answer 2

Platelet rich plasma is derived via centrifugation of whole blood and is rich in growth factors and cytokines, the factors promote healing and regeneration by inducing chemotaxis, cell migration and differentiation. Also contribute to angiogenesis and inflammatory changes which play a key role in tissue repair and regeneration.

Has been shown in small case series to possibly benefit those with POI, dimished ovarian reserve. Possibly older patients.

Question 3

Studies

Answer 3

1 RCT in <38yo with DOR. 40 in each arm. No difference in outcomes.

1 RCT posedin 3 and 4. 30 in each arm. Higher egg count in PRP arm, no difference for other outcomes.

Case series and meta-analysis showing higher number of embryos. Live birth rates around 10%

Question 4

Physiology of PRP

Answer 4