Others

Question 1

Hydralazine

Answer 1

⬆️cGMP
Vasodilator (A>V)
Afterload reduction

CLINICAL USE : severe HTN, HF, safe for pregnancy
To avoid tachycardia add beta blocker

Complications: tachycardia (contraindicated for angina and CAD), fluid retention, headache, angina, SLE-like syndrome

Question 2

Nitrates

Tng , isosurbide nitrate

Answer 2

Vasodilator V>A (⬇️preload)

Clinical use : angina, ACS, P. Edema

Contra : Lt V infarction

Complications: to avoid reflex tachy (like hydralazine) add beta blocker, hypotension, flushing, headache,

Monday disease (tachy, dizziness, headache)

Question 3

Ivabradine

Answer 3

Prolongs slow depolarization (phase iv) by selectively inhibiting funny sodium channel

Clinical use chronic stable angina in patients who cannot take beta blockers
Chronic HF

Adverse : luminous phenomena/visual brightness HTN bradycardia