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Heart Pharmacology > Cardiac Glycoside > Flashcards

Cardiac Glycoside Flashcards

1
Q

Dugoxin mechanism

A

Inhibit Na/K pump
Indirectly inhibit Na/Ca
⬆️ Ca inside

> > positive inotropy
Stimulate vagus nerve
⬇️HR

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2
Q

Clinical use if digoxin

A 
HF (⬆️contractility) 
Atrial fibrillation (⬇️conduction at AV node and SA depression)
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3
Q

Adverse effect of digoxin

A

Cholinergic (nausea vomiting diarrhea)
Blurry yellow vision (think Van Gogh)
Arrhythmia, AV block

Hyperkalemia (poor prognosis)

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4
Q

Dog toxicity predisposing factor

A

Renal failure
Hypokalemia
Drugs that displace digoxin from tissue binding sites, and ⬇️clearance : verapamil amiodarone quinidine

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5
Q

Tx of dig toxicity

A

Normalize K
Cardiac pacer
Anti dig Fab fragments
Mg

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Heart Pharmacology (9 decks)

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