Other metals 2 Flashcards
Copper interactions, acute tox, chronic tox, factors influencing tox
Mo, Zn, Fe, sulphate;
Acute tox: irritation– cramps, vom, diarrhea
chronic tox– hemolysis of RBCs; liver necrosis, decrease glutathione; methemoglobin formation
factors: ingestion liver disease; mineral imbalance; genetics (Muenke’s disease)
what is wilson’s disease, and what causes it?
Cu; Cu not excreted via biliary route due to autosomal recessive gene mutation; therefore Cu accumulates in liver
what is menkes disease?
opposite of wilson’s disease–inability to store Cu–>bone problems–die at 2 years
describe Mo toxicity
Causes Cu deficiency–>strong interaction b/w Mo and Cu–>decreases abs of Cu and increases excretion of Cu
alters activity of xanthine oxidase and aldehyde oxidase, which are dependent on Cu
wherever Cu is stored, Mo is found–>liver, kidney, blood
how is Mo excreted?
50% in urine
bile
biological effects of Mo?
- Interferes wth Cu storage
- Interferes with Cu enzymes–ceruloplasmin
- interferes with P abs
- Reduces phospholipid synth–>low P, membrane effects
- reduces ATP synth
clinical manifestations of Mo?
anemia, poor growth, diarrhea, joint deformities, depigmentation of wool/hair
treatment of Mo poisoning?
Cu!
what are the forms of Se, and what are the ones which cause major problems?
Selenate– Se 6+
Selenite– 4+
Selenide – 2+
Absorption of Se forms
Selenite (4+) – 90%
Selenide (2+) – 0%
Distribution of Selenite
liver, kidney, blood, brain, muscle
crosses placenta–teratogenic
Se metabolism?
methylation
Se excretion
Urine-- 15-40% Se-Met complex Milk Sweat as a dimethyl selenide (probably 2CH4 + Se4+ --> CH3--Se2+--CH3)--HAS GARLIC SMELL lungs--breath
what is the function of Se in our bodies?
important for GSH peroxidase–>has antioxidant activity again free rad, lipid perox, membrane damage
Acute tox of Se?
severe tissue destruction–lungs, breath problem
dyspnea, cyanosis, diarrhea (destroyed gut cells)
